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Gene RET
Variant C634W
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions RET C634W lies within the extracellular domain of the Ret protein (UniProt.org). C634W results in ligand independent dimerization and constitutive activation of Ret, and is transforming in culture (PMID: 10918602, PMID: 9230192).
Associated Drug Resistance
Category Variants Paths

RET mutant RET act mut RET C634W

RET mutant RET C634X RET C634W

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Transcript NM_020975.6
gDNA chr10:g.43114502C>G
cDNA c.1902C>G
Protein p.C634W
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020630 chr10:g.43114502C>G c.1902C>G p.C634W RefSeq GRCh38/hg38
NM_001406786.1 chr10:g.43123797C>G c.1902C>G p.C634W RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43114502C>G c.1902C>G p.C634W RefSeq GRCh38/hg38
NM_020975 chr10:g.43114502C>G c.1902C>G p.C634W RefSeq GRCh38/hg38
NM_001406783.1 chr10:g.43123797C>G c.1902C>G p.C634W RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43114502C>G c.1902C>G p.C634W RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43114502C>G c.1902C>G p.C634W RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43114502C>G c.1902C>G p.C634W RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43114502C>G c.1902C>G p.C634W RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43114502C>G c.1902C>G p.C634W RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43114502C>G c.1902C>G p.C634W RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43114502C>G c.1902C>G p.C634W RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries