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Gene JAK3
Variant L875H
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions JAK3 L875H lies within protein kinase domain 2 of the Jak3 protein (UniProt.org). L875H results in transforming activity (PMID: 29187379), receptor-independent Jak3 activation (PMID: 26446793), and demonstrates resistance to some JAK inhibitors in culture (PMID: 31976485).
Associated Drug Resistance Y
Category Variants Paths

JAK3 mutant JAK3 act mut JAK3 L875H

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Transcript NM_000215.4
gDNA chr19:g.17832575A>T
cDNA c.2624T>A
Protein p.L875H
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000215 chr19:g.17832575A>T c.2624T>A p.L875H RefSeq GRCh38/hg38
NM_000215.4 chr19:g.17832575A>T c.2624T>A p.L875H RefSeq GRCh38/hg38
NM_000215.3 chr19:g.17832575A>T c.2624T>A p.L875H RefSeq GRCh38/hg38
XM_047438786.1 chr19:g.17832575A>T c.2624T>A p.L875H RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
JAK3 L875H hematologic cancer predicted - sensitive Ruxolitinib Preclinical - Cell culture Actionable In a preclinical study, transformed cells expressing JAK3 L875H demonstrated some sensitivity to treatment with Jakafi (ruxolitinib) in culture, but were not as sensitive as cells expressing other JAK3 activating mutations (PMID: 31976485). 31976485
JAK3 L875H hematologic cancer predicted - sensitive Tofacitinib Preclinical - Cell culture Actionable In a preclinical study, transformed cells expressing JAK3 L875H demonstrated some sensitivity to treatment with Xeljanz (tofacitinib) in culture, but were not as sensitive as cells expressing other JAK3 activating mutations (PMID: 31976485). 31976485
JAK3 L875H hematologic cancer resistant Baricitinib Preclinical - Cell culture Actionable In a preclinical study, transformed cells expressing JAK3 L875H demonstrated resistance to treatment with Baricitinib (LY3009104) in culture (PMID: 31976485). 31976485
JAK3 L875H hematologic cancer predicted - sensitive Decernotinib Preclinical - Cell culture Actionable In a preclinical study, transformed cells expressing JAK3 L875H demonstrated some sensitivity to treatment with Decernotinib (VX-509) in culture, but were not as sensitive as cells expressing other JAK3 activating mutations (PMID: 31976485). 31976485
JAK3 L875H hematologic cancer predicted - sensitive ASP015K Preclinical - Cell culture Actionable In a preclinical study, transformed cells expressing JAK3 L875H demonstrated some sensitivity to treatment with ASP015K (peficitinib) in culture, but were not as sensitive as cells expressing other JAK3 activating mutations (PMID: 31976485). 31976485
JAK3 L875H hematologic cancer resistant Upadacitinib Preclinical - Cell culture Actionable In a preclinical study, transformed cells expressing JAK3 L875H demonstrated resistance to treatment with Rinvoq (upadacitinib) in culture (PMID: 31976485). 31976485