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Therapy Name Upadacitinib
Synonyms
Therapy Description

Rinvoq (upadacitinib) is an inhibitor of JAK1 and JAK3, which may lead to decreased cell proliferation (PMID: 31976485). Rinvoq (upadacitinib) is FDA approved for rheumatoid arthritis (FDA.gov).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Upadacitinib Rinvoq ABT 494|ABT-494 JAK1 Inhibitor 9 JAK3 Inhibitor 6 Rinvoq (upadacitinib) is an inhibitor of JAK1 and JAK3, which may lead to decreased cell proliferation (PMID: 31976485). Rinvoq (upadacitinib) is FDA approved for rheumatoid arthritis (FDA.gov).

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
JAK3 L875H hematologic cancer resistant Upadacitinib Preclinical - Cell culture Actionable In a preclinical study, transformed cells expressing JAK3 L875H demonstrated resistance to treatment with Rinvoq (upadacitinib) in culture (PMID: 31976485). 31976485
JAK3 L857Q hematologic cancer sensitive Upadacitinib Preclinical - Cell culture Actionable In a preclinical study, transformed cells expressing JAK3 L857Q were sensitive to treatment with Rinvoq (upadacitinib) in culture, demonstrating decreased cell proliferation (PMID: 31976485). 31976485

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries


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