ERBB3 E928A
Gene Variant Detail

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Gene ERBB3
Variant E928A
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions ERBB3 (HER3) E928A lies within the protein kinase domain of the Erbb3 (Her3) protein (UniProt.org). E928A (reported as E909A) results in increased Erbb2 (Her2) activation in cell culture (PMID: 23843458), and therefore, is predicted to lead to a gain of Erbb3 (Her3) protein function.
Associated Drug Resistance
Category Variants Paths

ERBB3 mutant ERBB3 act mut ERBB3 E928A

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Transcript NM_001982.4
gDNA chr12:g.56098849A>C
cDNA c.2783A>C
Protein p.E928A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001982.3 chr12:g.56098849A>C c.2783A>C p.E928A RefSeq GRCh38/hg38
NM_001982.4 chr12:g.56098849A>C c.2783A>C p.E928A RefSeq GRCh38/hg38
NM_001982 chr12:g.56098849A>C c.2783A>C p.E928A RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ERBB3 E928A triple-receptor negative breast cancer predicted - sensitive Capecitabine + Trastuzumab Case Reports/Case Series Actionable In a clinical case study, treatment with the combination of Herceptin (trastuzumab) and Xeloda (capecitabine) resulted in a partial response and reduction in circulating tumor markers, with clinical benefit ongoing after 10 months, in a triple-receptor negative breast cancer patient harboring ERBB3 (HER2) E928A who had previously progressed on several lines of therapy (PMID: 34250408). 34250408