BRAF I463S
Gene Variant Detail

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Gene BRAF
Variant I463S
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions BRAF I463S lies within the protein kinase domain of the Braf protein (UniProt.org). I463S results in an intermediate increase in Braf kinase activity compared to wild-type Braf and increased Erk activation in cell culture (PMID: 15035987).
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF act mut BRAF I463S

BRAF mutant BRAF I463X BRAF I463S

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Transcript NM_004333.6
gDNA chr7:g.140781620A>C
cDNA c.1388T>G
Protein p.I463S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001378474.1 chr7:g.140781620A>C c.1388T>G p.I463S RefSeq GRCh38/hg38
NM_001378475.1 chr7:g.140776954A>C c.1388T>G p.I463S RefSeq GRCh38/hg38
XM_005250045 chr7:g.140781620A>C c.1388T>G p.I463S RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140781620A>C c.1388T>G p.I463S RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140781620A>C c.1388T>G p.I463S RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140781620A>C c.1388T>G p.I463S RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.140781620A>C c.1388T>G p.I463S RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140781620A>C c.1388T>G p.I463S RefSeq GRCh38/hg38
NM_004333 chr7:g.140781620A>C c.1388T>G p.I463S RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140781620A>C c.1388T>G p.I463S RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References