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Gene BRAF
Variant R462I
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF R462I lies within the protein kinase domain of the Braf protein (UniProt.org). R462I results in activation of Braf and increased Erk signaling in cell culture (PMID: 15035987), but induced cell proliferation and cell viability similar to wild-type Braf in two different cell lines in culture (PMID: 29533785), and therefore, its effect on Braf protein function is unknown.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF R462X BRAF R462I

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Transcript NM_004333.6
gDNA chr7:g.140781623C>A
cDNA c.1385G>T
Protein p.R462I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001354609.2 chr7:g.140781623C>A c.1385G>T p.R462I RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140781623C>A c.1385G>T p.R462I RefSeq GRCh38/hg38
NM_004333 chr7:g.140781623C>A c.1385G>T p.R462I RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140781623C>A c.1385G>T p.R462I RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140781623C>A c.1385G>T p.R462I RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140781623C>A c.1385G>T p.R462I RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140781623C>A c.1385G>T p.R462I RefSeq GRCh38/hg38
XM_005250045 chr7:g.140781623C>A c.1385G>T p.R462I RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.140781623C>A c.1385G>T p.R462I RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries