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Gene BRAF
Variant P403fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions BRAF P403fs results in a change in the amino acid sequence of the Braf protein beginning at aa 403 of 766, likely resulting in premature truncation of the functional protein (UniProt.org). Due to the loss of the protein kinase domain (UniProt.org), P403fs is predicted to lead to a loss of Braf protein function.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF inact mut BRAF P403fs

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Transcript NM_004333.6
gDNA chr7:g.(140783128_140783129)
cDNA c.(1207_1206)
Protein p.P403fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004333.5 chr7:g.(140783128_140783129) c.(1207_1206) p.P403fs RefSeq GRCh38/hg38
NM_004333.6 chr7:g.(140783128_140783129) c.(1207_1206) p.P403fs RefSeq GRCh38/hg38
XM_005250045 chr7:g.(140783128_140783129) c.(1207_1206) p.P403fs RefSeq GRCh38/hg38
NM_004333 chr7:g.(140783128_140783129) c.(1207_1206) p.P403fs RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.(140783128_140783129) c.(1207_1206) p.P403fs RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.(140783128_140783129) c.(1207_1206) p.P403fs RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.(140783128_140783129) c.(1207_1206) p.P403fs RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.(140783128_140783129) c.(1207_1206) p.P403fs RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.(140783128_140783129) c.(1207_1206) p.P403fs RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
BRAF P403fs loss of function - predicted