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Gene MAP2K1
Variant I99G
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions MAP2K1 I99G lies within the protein kinase domain of the Map2k1 protein (UniProt.org). I99G results in increased Erk2 phosphorylation and confers resistance to some Mek and Braf inhibitors in culture (PMID: 31925410), and therefore, is predicted to lead to a gain of Map2k1 protein function.
Associated Drug Resistance Y
Category Variants Paths

MAP2K1 mutant MAP2K1 act mut MAP2K1 I99G

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Transcript NM_002755.4
gDNA chr15:g.66436749_66436750delATinsGG
cDNA c.295_296delATinsGG
Protein p.I99G
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002755.3 chr15:g.66436749_66436750delATinsGG c.295_296delATinsGG p.I99G RefSeq GRCh38/hg38
NM_002755 chr15:g.66436749_66436750delATinsGG c.295_296delATinsGG p.I99G RefSeq GRCh38/hg38
XM_017022411 chr15:g.66436749_66436750delATinsGG c.295_296delATinsGG p.I99G RefSeq GRCh38/hg38
NM_002755.4 chr15:g.66436749_66436750delATinsGG c.295_296delATinsGG p.I99G RefSeq GRCh38/hg38
XM_017022411.2 chr15:g.66436749_66436750delATinsGG c.295_296delATinsGG p.I99G RefSeq GRCh38/hg38
XM_017022411.3 chr15:g.66436749_66436750delATinsGG c.295_296delATinsGG p.I99G RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References