NRAS G12V
Gene Variant Detail

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Gene NRAS
Variant G12V
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions NRAS G12V is a hotspot mutation that lies within a GTP-binding region of the Nras protein (UniProt.org). G12V confers a loss of function on Nras protein as indicated by accumulation of GTP-bound Nras, loss of GTPase-activating protein sensitivity, leading to increased downstream pathway activation in cell culture (PMID: 19966803).
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS act mut NRAS G12V

NRAS mutant NRAS exon2 NRAS G12X NRAS G12V

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Transcript NM_002524.5
gDNA chr1:g.114716126C>A
cDNA c.35G>T
Protein p.G12V
Source Database RefSeq
Genome Build GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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