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NRAS Q61H - Gene Variant Detail

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Gene NRAS
Variant Q61H
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions NRAS Q61H is a hotspot mutation that lies within a GTP-binding region of the Nras protein (UniProt.org). Q61H results in increased GTP-bound Nras, downstream pathway activation, and increased cell proliferation in culture (PMID: 23103856), and is predicted to lead to a loss of Nras protein function based on the effects of HRAS Q61H (PMID: 3510078) and KRAS Q61H (PMID: 20147967).
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS act mut NRAS Q61H

NRAS mutant NRAS exon3 NRAS Q61X NRAS Q61H

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Transcript NM_002524.5
gDNA chr1:g.114713907T>A
cDNA c.183A>T
Protein p.Q61H
Source Database RefSeq
Genome Build GRCh38/hg38

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