mucosal melanoma
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ID DOID:0050929
Name mucosal melanoma
Definition A melanoma that has_material_basis_in melanocytes located_in mucosal membranes lining the respiratory, gastrointestinal and urogenital tract.
Source DiseaseOntology.org
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Path disease disease of cellular proliferation cancer cell type cancer melanoma mucosal melanoma

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
KIT C443S Imatinib mucosal melanoma sensitive detail...
BRAF V600L Dabrafenib + Trametinib mucosal melanoma predicted - sensitive detail...
KIT N822K Avapritinib mucosal melanoma predicted - sensitive detail...
KIT exon17 Avapritinib mucosal melanoma predicted - sensitive detail...
EML4 - ALK Crizotinib mucosal melanoma sensitive detail...
EML4 - ALK Ceritinib mucosal melanoma sensitive detail...
EML4 - ALK Entrectinib mucosal melanoma sensitive detail...
EML4 - ALK ASP3026 mucosal melanoma sensitive detail...
EML4 - ALK Alectinib mucosal melanoma sensitive detail...
NRAS Q61H Trametinib mucosal melanoma sensitive detail...
NRAS Q61L Belvarafenib mucosal melanoma predicted - sensitive detail...
BRAF D594G Belvarafenib mucosal melanoma predicted - sensitive detail...
KIT V560D Imatinib mucosal melanoma predicted - sensitive detail...
KIT D820Y Imatinib mucosal melanoma predicted - sensitive detail...
KIT K642E Imatinib mucosal melanoma predicted - sensitive detail...
KIT mutant Nilotinib mucosal melanoma predicted - sensitive detail...
KIT D820V Nilotinib mucosal melanoma predicted - sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT02645149 Phase II Trametinib Pazopanib Ceritinib Ribociclib + Trametinib Molecular Profiling and Matched Targeted Therapy for Patients With Metastatic Melanoma (MatchMel) Active, not recruiting AUS 0
NCT02748564 Phase II Aldesleukin + Pembrolizumab Aldesleukin and Pembrolizumab in Treating Patients With Stage III-IV Melanoma Terminated USA 0
NCT02818023 Phase I Cobimetinib + Pembrolizumab + Vemurafenib Dose-seeking Study of Pembrolizumab Plus Vemurafenib and Cobimetinib Advanced Melanoma Terminated USA 0
NCT02879162 Phase II Durvalumab + Tremelimumab Durvalumab and Tremelimumab in Patients With Advanced Rare Tumours Completed CAN 0
NCT02978443 Phase II Ipilimumab + Nivolumab A Biomarker Study in Advanced Mucosal or Acral Lentiginous Melanoma Receiving Nivolumab in Combination With Ipilimumab Terminated USA 0
NCT03220009 Phase II Ipilimumab + Nivolumab Nivolumab or Expectant Observation Following Ipilimumab, Nivolumab, and Surgery in Treating Patients With High Risk Localized, Locoregionally Advanced, or Recurrent Mucosal Melanoma Withdrawn USA 0
NCT03235245 Phase II Binimetinib + Encorafenib Ipilimumab + Nivolumab Immunotherapy With Ipilimumab and Nivolumab Preceded or Not by a Targeted Therapy With Encorafenib and Binimetinib (EBIN) Active, not recruiting POL | NLD | ITA | GBR | FRA | FIN | ESP | DNK | DEU 0
NCT03241186 Phase II Ipilimumab + Nivolumab Ipilimumab and Nivolumab as Adjuvant Treatment of Mucosal Melanoma Active, not recruiting USA 0
NCT03313206 Phase II Pembrolizumab Neoadjuvant Treatment Associated With Maintenance Therapy by Anti-PD1 Immunotherapy in Patients With Resectable Head and Neck Mucosal Melanoma (IMMUQ) Recruiting FRA 0
NCT03340129 Phase II Ipilimumab + Nivolumab Anti-PD 1 Brain Collaboration + Radiotherapy Extension (ABC-X Study) (ABC-X) Recruiting SWE | NOR | AUS 0
NCT03817125 Phase I Nivolumab + SER-401 Vancomycin Nivolumab Melanoma Checkpoint and Gut Microbiome Alteration With Microbiome Intervention (MCGRAW) Completed USA 0
NCT03875079 Phase I Pembrolizumab + RO6874281 A Phase IB Study To Evaluate Safety And Therapeutic Activity Of RO6874281, An Immunocytokine, Consisting Of Interleukin-2 Variant Targeting Fibroblast Activation Protein-A, In Combination With Pembrolizumab (Anti-Pd-1), In Participants With Previously Untreated Advanced And/Or Metastatic Melanoma Completed USA | FRA | ESP | CAN | BEL | AUS 1
NCT03991741 Phase I Aldesleukin Adoptive Cell Transfer of Autologous Tumor Infiltrating Lymphocytes and High-Dose Interleukin 2 in Select Solid Tumors Terminated USA 0
NCT04042506 Phase II Nivolumab SBRT as a Vaccination for Metastatic Melanoma Withdrawn USA 0
NCT04139902 Phase II Cobolimab + Dostarlimab-gxly Dostarlimab-gxly PD-1 Inhibitor Dostarlimab (TSR-042) vs. Combination of Tim-3 Inhibitor TSR-022 and PD-1 Inhibitor Dostarlimab (TSR-042) Active, not recruiting USA 0
NCT04250597 Phase I GNX102 Study of GNX102 in Patients With Advanced Solid Tumors Terminated USA 1
NCT04318717 Phase Ib/II Pembrolizumab Pembrolizumab and Hypofractionated Radiation Therapy for the Treatment of Mucosal Melanoma Recruiting USA 0
NCT04493203 Phase II Axitinib + Nivolumab Nivolumab Plus Axitinib in Patients With Anti-PD1 Refractory Advanced Melanoma Completed USA 0
NCT04551352 Phase I RO7293583 + Tocilizumab Obinutuzumab + RO7293583 + Tocilizumab A Study of RO7293583 in Participants With Unresectable Metastatic Tyrosinase Related Protein 1 (TYRP1)-Positive Melanomas Completed USA | ESP | DNK | CAN | BEL | AUS 0
NCT04570332 Phase II BO-112 + Pembrolizumab BO-112 With Pembrolizumab in Unresectable Malignant Melanoma (SPOTLIGHT203) Completed FRA | ESP 0
NCT04577807 Phase II PVSRIPO + unspecified PD-1 antibody PVSRIPO PVSRIPO With or Without Immune Checkpoint Blockade in Patients With Advanced PD-1 Refractory Melanoma Completed USA 0
NCT04592653 Phase Ib/II ALKS 4230 ALKS 4230 + Pembrolizumab Less Frequent IV Dosing & Tumor Microenvironment (TME) Study of Nemvaleukin Alfa (ALKS 4230) Monotherapy and in Combination With Pembrolizumab (ARTISTRY-3) (ARTISTRY-3) Active, not recruiting USA | ESP 0
NCT04830124 Phase II ALKS 4230 Nemvaleukin Alfa (ALKS 4230) Monotherapy in Patients With Advanced Cutaneous Melanoma or Advanced Mucosal Melanoma - ARTISTRY-6 (ARTISTRY-6) Terminated USA | ITA | GBR | ESP | CAN | AUS 2
NCT04987996 Phase II Pembrolizumab Belapectin + Pembrolizumab GR-MD-02 + Pembrolizumab Versus Pembrolizumab Monotherapy in Melanoma and Squamous Cell Head and Neck Cancer Patients Withdrawn USA 0
NCT05061134 Phase II Ceralasertib + Durvalumab Ceralasertib A Study of Ceralasertib Monotherapy and Ceralasertib Plus Durvalumab in Patients With Melanoma and Resistance to PD-(L)1 Inhibition (MONETTE) Active, not recruiting USA | POL | ITA | GBR | FRA | ESP | DEU | CAN | BEL | AUS 1
NCT05086692 Phase Ib/II MDNA11 + Pembrolizumab A Beta-only IL-2 ImmunoTherapY Study (ABILITY-1) Recruiting USA | IRL | ESP | CAN | AUS 2
NCT05089370 Phase Ib/II Decitabine and Cedazuridine + Nivolumab Oral Decitabine/Cedazuridine (DEC-C) in Combination With Nivolumab for Patients With Mucosal Melanoma Active, not recruiting USA 0
NCT05098210 Phase I NeoVax + Nivolumab + Poly ICLC Personalized Neo-Antigen Peptide Vaccine for the Treatment of Stage IIIC-IV Melanoma or Hormone Receptor Positive Her2 Negative Metastatic Refractory Breast Cancer Recruiting USA 0
NCT05111574 Phase II Nivolumab Cabozantinib + Nivolumab Using Nivolumab Alone or With Cabozantinib to Prevent Mucosal Melanoma Return After Surgery Recruiting USA | CAN 0
NCT05384496 Phase II Axitinib + Ipilimumab + Nivolumab Axitinib + Nivolumab Axitinib and Nivolumab for the Treatment of Mucosal Melanoma Recruiting USA 0
NCT05415072 Phase Ib/II DYP688 A Phase I/II Study of DYP688 in Patients With Metastatic Uveal Melanoma and Other GNAQ/11 Mutant Melanomas Active, not recruiting USA | NLD | FRA | ESP | DEU | CHE | AUS 0
NCT05428007 Phase II Ipilimumab + Nivolumab and relatlimab-rmbw + Sarilumab Interleukin-6 Receptor Inhibitor Sarilumab in Combination With Ipilimumab, Nivolumab and Relatlimab in Patients With Unresectable Stage III or Stage IV Melanoma Recruiting USA 0
NCT05482074 Phase II Olaparib Olaparib in Unresectable/Metastatic Melanoma With BRCA1/2 Withdrawn 0
NCT05545969 Phase II Lenvatinib + Pembrolizumab Neoadjuvant Pembrolizumab and Lenvatinib for Mucosal Melanoma (Neo PeLeMM) Withdrawn AUS 0
NCT05628883 Phase I Cyclophosphamide + Fludarabine TBio-4101 Aldesleukin Proof of Concept of TBio-4101, Lymphodepleting Chemo, IL-2 for Relapsed/Refractory Melanoma Active, not recruiting USA 0
NCT05913388 Phase II Pembrolizumab GB1211 + Pembrolizumab GB1211 and Pembrolizumab Versus Pembrolizumab and Placebo in Patients With Metastatic Melanoma and Head and Neck Squamous Cell Carcinoma Recruiting USA 0
NCT06319196 Phase II Nivolumab Nivolumab and relatlimab-rmbw Clear Me: Interception Trial to Detect and Clear Molecular Residual Disease in Patients With High-risk Melanoma (ClearMe) Recruiting CAN 0
NCT06594991 Phase II Cemiplimab + Fianlimab + Ipilimumab A Study of Fianlimab, Cemiplimab, and Ipilimumab in People With Melanoma Recruiting USA 0
NCT06598371 Phase Ib/II Cyclophosphamide + Fludarabine Aldesleukin + KSQ-004EX KSQ-004EX A Phase 1/2 Study of KSQ-004EX, Autologous Tumor Infiltrating Lymphocytes Engineered to Inactivate Genes Encoding SOCS1 and Regnase-1, in Patients With Select Advanced Solid Tumors Recruiting USA 0
NCT06651151 Phase II LTX-315 + Pembrolizumab NeoLIPA: Neoadjuvant LTX-315 in Combination With Pembrolizumab in Resectable Stage III/IV Melanoma (NeoLIPA) Recruiting NOR 0
NCT06660420 Phase I PRAME-TCR-NK cells Cyclophosphamide + Fludarabine Phase 1 Dose Escalation and Expansion Study of PRAME T Cell Receptor (TCR) Engineered NK Cells in Participants With Recurrent and/or Refractory Melanoma (PRAMETIME-Mel) Recruiting USA 0
NCT06961357 Phase Ib/II Interleukin-12 CD40L-augmented TILs Cyclophosphamide + Fludarabine Clinical Trial of CD40L-augmented TIL for Patients With Advanced Melanoma Recruiting USA 0
NCT06999980 Phase II Ipilimumab + Nivolumab Nivolumab + Relatlimab Ipilimumab + Nivolumab + Relatlimab A Phase II, Randomised Clinical Trial of Nivolumab and Ipilimumab Combined With Relatlimab for Patients With Resectable Advanced Melanoma Identified as Poor Responders to Immunotherapy Neo IRENIE (NEOadjuvant Ipilimumab, RElatlimab, NIvolumab Evaluation) (Neo IRENIE) Not yet recruiting AUS 0
NCT07070232 Phase Ib/II BNT327 + YL202 YL202 Itraconazole + YL202 A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and Potentially Beneficial When Used Alone or in Combination With Other Investigational Treatments Such as BNT327, for People With Advanced Malignant Tumors Recruiting USA | GBR | AUS 0
NCT07155317 Phase II Ipilimumab + Nivolumab Time-of-Day Specified Immunotherapy for Advanced Melanoma, The TIME Trial Recruiting USA 0