Gene Variant Detail

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Gene RET
Variant C618F
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions RET C618F lies within the extracellular domain of the Ret protein (UniProt.org). C618F results in elevated basal and ligand-induced phosphorylation levels and decreased cell surface expression in culture (PMID: 30884088), and therefore, is predicted to lead to a gain of Ret protein function.
Associated Drug Resistance
Category Variants Paths

RET mutant RET act mut RET C618F

RET mutant RET C618X RET C618F

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Transcript NM_020975.6
gDNA chr10:g.43113649G>T
cDNA c.1853G>T
Protein p.C618F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406760.1 chr10:g.43113649G>T c.1853G>T p.C618F RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43113649G>T c.1853G>T p.C618F RefSeq GRCh38/hg38
NM_020975 chr10:g.43113649G>T c.1853G>T p.C618F RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43113649G>T c.1853G>T p.C618F RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43113649G>T c.1853G>T p.C618F RefSeq GRCh38/hg38
NM_001406765.1 chr10:g.43113649G>T c.1853G>T p.C618F RefSeq GRCh38/hg38
NM_001406763.1 chr10:g.43113649G>T c.1853G>T p.C618F RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43113649G>T c.1853G>T p.C618F RefSeq GRCh38/hg38
NM_020630 chr10:g.43113649G>T c.1853G>T p.C618F RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43113649G>T c.1853G>T p.C618F RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43113649G>T c.1853G>T p.C618F RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43113649G>T c.1853G>T p.C618F RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
RET C618F gain of function - predicted RET Inhibitor