MAP2K1 E41_F53del
Gene Variant Detail

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Gene MAP2K1
Variant E41_F53del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions MAP2K1 E41_F53del results in the deletion of 13 amino acids in the Map2k1 protein from amino acids 41 to 53 (UniProt.org). E41_F53del has been identified in the scientific literature (PMID: 32483240, PMID: 33289976), but has not been biochemically characterized and therefore, its effect on Map2k1 protein function is unknown (PubMed, Dec 2025).
Associated Drug Resistance
Category Variants Paths

MAP2K1 mutant MAP2K1 E41_F53del

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Transcript NM_002755.4
gDNA chr15:g.66435067_66435105del39
cDNA c.121_159del39
Protein p.E41_F53del
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017022411.3 chr15:g.66435067_66435105del39 c.121_159del39 p.E41_F53del RefSeq GRCh38/hg38
NM_002755.4 chr15:g.66435067_66435105del39 c.121_159del39 p.E41_F53del RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References