HRAS G12D - Gene Variant Detail

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Gene HRAS
Variant G12D
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions HRAS G12D does not lie within any known functional domains of the Hras protein (UniProt.org). G12D results in decreased Hras GTPase activity, loss of sensitivity to GTPase-activating proteins, thus leads to transformation of cells in culture (PMID: 24224811, PMID: 6092966).
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS act mut HRAS G12D

HRAS mutant HRAS G12X HRAS G12D

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Transcript NM_005343.4
gDNA chr11:g.534288C>T
cDNA c.35G>A
Protein p.G12D
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_005343.4 chr11:g.534288C>T c.35G>A p.G12D RefSeq GRCh38/hg38
NM_005343 chr11:g.534288C>T c.35G>A p.G12D RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.534288C>T c.35G>A p.G12D RefSeq GRCh38/hg38
NM_176795.4 chr11:g.534288C>T c.35G>A p.G12D RefSeq GRCh38/hg38
NM_176795.5 chr11:g.534288C>T c.35G>A p.G12D RefSeq GRCh38/hg38
NM_176795 chr11:g.534288C>T c.35G>A p.G12D RefSeq GRCh38/hg38
NM_005343.3 chr11:g.534288C>T c.35G>A p.G12D RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.534288C>T c.35G>A p.G12D RefSeq GRCh38/hg38
NM_001130442 chr11:g.534288C>T c.35G>A p.G12D RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
HRAS G12D HRAS Q95H Advanced Solid Tumor sensitive MRTX-1133 Preclinical - Cell culture Actionable In a preclinical study, cultured cells expressing HRAS G12D and HRAS Q95H were sensitive to treatment with MRTX1133, demonstrating decreased cell viability (PMID: 37339170). 37339170