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Therapy Name	MRTX-1133
Synonyms
Therapy Description	MRTX-1133 selectively inhibits KRAS G12D, which results in decreased downstream signaling and potentially leads to reduced tumor growth (PMID: 34889605).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
MRTX-1133		MRTX1133\|MRTX 1133	KRAS G12D Inhibitor 21	MRTX-1133 selectively inhibits KRAS G12D, which results in decreased downstream signaling and potentially leads to reduced tumor growth (PMID: 34889605).

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
HRAS G12D	Advanced Solid Tumor	no benefit	MRTX-1133	Preclinical - Cell culture	Actionable	In a preclinical study, cultured cells expressing HRAS G12D were not sensitive to treatment with MRTX1133 (PMID: 37339170).	37339170
HRAS G12D HRAS Q95H	Advanced Solid Tumor	sensitive	MRTX-1133	Preclinical - Cell culture	Actionable	In a preclinical study, cultured cells expressing HRAS G12D and HRAS Q95H were sensitive to treatment with MRTX1133, demonstrating decreased cell viability (PMID: 37339170).	37339170
NRAS G12D	multiple myeloma	no benefit	MRTX-1133	Preclinical - Cell culture	Actionable	In a preclinical study, a multiple myeloma cell line harboring NRAS G12D was not sensitive to treatment with MRTX1133 in culture (PMID: 37339170).	37339170
NRAS G12D	Advanced Solid Tumor	no benefit	MRTX-1133	Preclinical - Cell culture	Actionable	In a preclinical study, cultured cells expressing NRAS G12D were not sensitive to treatment with MRTX1133 (PMID: 37339170).	37339170
NRAS G12D NRAS L95H	Advanced Solid Tumor	sensitive	MRTX-1133	Preclinical - Cell culture	Actionable	In a preclinical study, cultured cells expressing NRAS G12D and NRAS L95H were sensitive to treatment with MRTX1133, demonstrating decreased cell viability (PMID: 37339170).	37339170

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Clinical Trial	Phase	Therapies	Title	Recruitment Status	Covered Countries	Other Countries
NCT05737706	Phase Ib/II	MRTX-1133	Study of MRTX1133 in Patients With Advanced Solid Tumors Harboring a KRAS G12D Mutation	Terminated	USA	0

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