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Gene MAP2K1
Variant A106_I107del
Impact List deletion
Protein Effect gain of function - predicted
Gene Variant Descriptions MAP2K1 A106_I107del results in the deletion of two amino acids in the protein kinase domain of the Map2k1 protein from amino acids 106 to 107 (UniProt.org). A106_I107del results in increased Erk phosphorylation in cultured cells (PMID: 32641410), and therefore, is predicted to lead to a gain of Map2k1 protein function.
Associated Drug Resistance
Category Variants Paths

MAP2K1 mutant MAP2K1 act mut MAP2K1 A106_I107del

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Transcript NM_002755.4
gDNA chr15:g.66436770_66436775delGCAATC
cDNA c.316_321delGCAATC
Protein p.A106_I107delAI
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017022411.3 chr15:g.66436770_66436775delGCAATC c.316_321delGCAATC p.A106_I107delAI RefSeq GRCh38/hg38
XM_017022413.1 chr15:g.66485141_66485146delATGCGG c.317_322delATGCGG p.D106_A107delDA RefSeq GRCh38/hg38
XM_017022413 chr15:g.66485141_66485146delATGCGG c.317_322delATGCGG p.D106_A107delDA RefSeq GRCh38/hg38
NM_002755.3 chr15:g.66436770_66436775delGCAATC c.316_321delGCAATC p.A106_I107delAI RefSeq GRCh38/hg38
XM_011521783 chr15:g.66436836_66436841delGGCTTC c.316_321delGGCTTC p.G106_F107delGF RefSeq GRCh38/hg38
XM_011521783.3 chr15:g.66436836_66436841delGGCTTC c.316_321delGGCTTC p.G106_F107delGF RefSeq GRCh38/hg38
NM_001411065.1 chr15:g.66436836_66436841delGGCTTC c.316_321delGGCTTC p.G106_F107delGF RefSeq GRCh38/hg38
XM_017022412 chr15:g.66436836_66436841delGGCTTC c.316_321delGGCTTC p.G106_F107delGF RefSeq GRCh38/hg38
XM_011521783.4 chr15:g.66436836_66436841delGGCTTC c.316_321delGGCTTC p.G106_F107delGF RefSeq GRCh38/hg38
XM_017022411.2 chr15:g.66436770_66436775delGCAATC c.316_321delGCAATC p.A106_I107delAI RefSeq GRCh38/hg38
NM_002755 chr15:g.66436770_66436775delGCAATC c.316_321delGCAATC p.A106_I107delAI RefSeq GRCh38/hg38
XM_017022411 chr15:g.66436770_66436775delGCAATC c.316_321delGCAATC p.A106_I107delAI RefSeq GRCh38/hg38
NM_002755.4 chr15:g.66436770_66436775delGCAATC c.316_321delGCAATC p.A106_I107delAI RefSeq GRCh38/hg38
XM_017022412.1 chr15:g.66436836_66436841delGGCTTC c.316_321delGGCTTC p.G106_F107delGF RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Protein Effect Treatment Approaches
MAP2K1 A106_I107del gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor