Gene Variant Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene MAP2K1
Variant H100_L101del
Impact List deletion
Protein Effect no effect - predicted
Gene Variant Descriptions MAP2K1 H100_L101del results in the deletion of two amino acids in the protein kinase domain of the Map2k1 protein from amino acids 100 to 101 (UniProt.org). H100_L101del induces Erk phosphorylation similar to wild-type Map2k1 in cultured cells (PMID: 32641410), and therefore, is predicted to have no effect on Map2k1 protein function.
Associated Drug Resistance
Category Variants Paths

MAP2K1 mutant MAP2K1 H100_L101del

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_002755.4
gDNA chr15:g.66436752_66436757delCATCTG
cDNA c.298_303delCATCTG
Protein p.H100_L101delHL
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017022411 chr15:g.66436752_66436757delCATCTG c.298_303delCATCTG p.H100_L101delHL RefSeq GRCh38/hg38
XM_011521783.3 chr15:g.66436818_66436823delAACTCT c.298_303delAACTCT p.N100_S101delNS RefSeq GRCh38/hg38
XM_017022411.3 chr15:g.66436752_66436757delCATCTG c.298_303delCATCTG p.H100_L101delHL RefSeq GRCh38/hg38
XM_017022413 chr15:g.66485122_66485127delGGGTGC c.298_303delGGGTGC p.G100_C101delGC RefSeq GRCh38/hg38
XM_011521783 chr15:g.66436818_66436823delAACTCT c.298_303delAACTCT p.N100_S101delNS RefSeq GRCh38/hg38
XM_017022411.2 chr15:g.66436752_66436757delCATCTG c.298_303delCATCTG p.H100_L101delHL RefSeq GRCh38/hg38
NM_001411065.1 chr15:g.66436818_66436823delAACTCT c.298_303delAACTCT p.N100_S101delNS RefSeq GRCh38/hg38
XM_017022412 chr15:g.66436818_66436823delAACTCT c.298_303delAACTCT p.N100_S101delNS RefSeq GRCh38/hg38
XM_017022413.1 chr15:g.66485122_66485127delGGGTGC c.298_303delGGGTGC p.G100_C101delGC RefSeq GRCh38/hg38
XM_017022412.1 chr15:g.66436818_66436823delAACTCT c.298_303delAACTCT p.N100_S101delNS RefSeq GRCh38/hg38
NM_002755 chr15:g.66436752_66436757delCATCTG c.298_303delCATCTG p.H100_L101delHL RefSeq GRCh38/hg38
NM_002755.3 chr15:g.66436752_66436757delCATCTG c.298_303delCATCTG p.H100_L101delHL RefSeq GRCh38/hg38
NM_002755.4 chr15:g.66436752_66436757delCATCTG c.298_303delCATCTG p.H100_L101delHL RefSeq GRCh38/hg38
XM_011521783.4 chr15:g.66436818_66436823delAACTCT c.298_303delAACTCT p.N100_S101delNS RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
MAP2K1 H100_L101del no effect - predicted