Gene Variant Detail

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Gene MAP2K1
Variant K97_L98del
Impact List deletion
Protein Effect no effect - predicted
Gene Variant Descriptions MAP2K1 K97_L98del results in the deletion of two amino acids in the protein kinase domain of the Map2k1 protein from amino acids 97 to 98 (UniProt.org). K97_L98del induces Erk phosphorylation similar to wild-type Map2k1 in cultured cells (PMID: 32641410), and therefore, is predicted to have no effect on Map2k1 protein function.
Associated Drug Resistance
Category Variants Paths

MAP2K1 mutant MAP2K1 K97_L98del

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Transcript NM_002755.4
gDNA chr15:g.66435236_66436749del1514
cDNA c.290_295del1514
Protein p.K97_L98delKL
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002755 chr15:g.66435236_66436749del1514 c.290_295del1514 p.K97_L98delKL RefSeq GRCh38/hg38
XM_017022413 chr15:g.66485113_66485118delCTGATG c.289_294delCTGATG p.L97_M98delLM RefSeq GRCh38/hg38
XM_011521783.3 chr15:g.66436809_66436814delCATGAG c.289_294delCATGAG p.H97_E98delHE RefSeq GRCh38/hg38
NM_002755.3 chr15:g.66435236_66436749del1514 c.290_295del1514 p.K97_L98delKL RefSeq GRCh38/hg38
XM_011521783 chr15:g.66436809_66436814delCATGAG c.289_294delCATGAG p.H97_E98delHE RefSeq GRCh38/hg38
XM_017022411.3 chr15:g.66435236_66436749del1514 c.290_295del1514 p.K97_L98delKL RefSeq GRCh38/hg38
XM_011521783.4 chr15:g.66436809_66436814delCATGAG c.289_294delCATGAG p.H97_E98delHE RefSeq GRCh38/hg38
XM_017022411.2 chr15:g.66435236_66436749del1514 c.290_295del1514 p.K97_L98delKL RefSeq GRCh38/hg38
XM_017022413.1 chr15:g.66485113_66485118delCTGATG c.289_294delCTGATG p.L97_M98delLM RefSeq GRCh38/hg38
XM_017022412 chr15:g.66436809_66436814delCATGAG c.289_294delCATGAG p.H97_E98delHE RefSeq GRCh38/hg38
NM_002755.4 chr15:g.66435236_66436749del1514 c.290_295del1514 p.K97_L98delKL RefSeq GRCh38/hg38
XM_017022412.1 chr15:g.66436809_66436814delCATGAG c.289_294delCATGAG p.H97_E98delHE RefSeq GRCh38/hg38
NM_001411065.1 chr15:g.66436809_66436814delCATGAG c.289_294delCATGAG p.H97_E98delHE RefSeq GRCh38/hg38
XM_017022411 chr15:g.66435236_66436749del1514 c.290_295del1514 p.K97_L98delKL RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References