Gene Variant Detail

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Gene BRAF
Variant K601T
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions BRAF K601T lies within the activation segment in the kinase domain of the Braf protein (PMID: 15343278). K601T results in increased Braf kinase activity in cell culture (PMID: 28783719), and in one of two cell lines increased cell proliferation and cell viability compared to wild-type Braf (PMID: 29533785), and therefore, is predicted to lead to a gain of Braf protein function.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF act mut BRAF K601T

BRAF mutant BRAF K601X BRAF K601T

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Transcript NM_004333.6
gDNA chr7:g.140753333T>G
cDNA c.1802A>C
Protein p.K601T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004333 chr7:g.140753333T>G c.1802A>C p.K601T RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140753333T>G c.1802A>C p.K601T RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140753333T>G c.1802A>C p.K601T RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140753333T>G c.1802A>C p.K601T RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140753333T>G c.1802A>C p.K601T RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140753333T>G c.1802A>C p.K601T RefSeq GRCh38/hg38
XM_005250045 chr7:g.140753333T>G c.1802A>C p.K601T RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140753333T>G c.1802A>C p.K601T RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF K601T Advanced Solid Tumor resistant Vemurafenib Preclinical - Cell culture Actionable In a preclinical study, Zelboraf (vemurafenib) did not inhibit MEK and ERK activation in transformed cells over expressing the constitutively dimerized BRAF K601T (PMID: 26343582). 26343582