Gene Variant Detail

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Gene MAP2K1
Variant A95_R96del
Impact List deletion
Protein Effect no effect - predicted
Gene Variant Descriptions MAP2K1 A95_R96del results in the deletion of two amino acids in the protein kinase domain of the Map2k1 protein from amino acids 95 to 96 (UniProt.org). A95_R96del induces Erk phosphorylation similar to wild-type Map2k1 in cultured cells (PMID: 32641410), and therefore, is predicted to have no effect on Map2k1 protein function.
Associated Drug Resistance
Category Variants Paths

MAP2K1 mutant MAP2K1 A95_R96del

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Transcript NM_002755.4
gDNA chr15:g.66435229_66435234delGCCAGA
cDNA c.283_288delGCCAGA
Protein p.A95_R96delAR
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017022412.1 chr15:g.66436803_66436808delGTTCTG c.283_288delGTTCTG p.V95_L96delVL RefSeq GRCh38/hg38
XM_017022411.3 chr15:g.66435229_66435234delGCCAGA c.283_288delGCCAGA p.A95_R96delAR RefSeq GRCh38/hg38
XM_011521783.4 chr15:g.66436803_66436808delGTTCTG c.283_288delGTTCTG p.V95_L96delVL RefSeq GRCh38/hg38
XM_017022413 chr15:g.66485110_66485115delGAGCTG c.286_291delGAGCTG p.E96_L97delEL RefSeq GRCh38/hg38
NM_002755.3 chr15:g.66435229_66435234delGCCAGA c.283_288delGCCAGA p.A95_R96delAR RefSeq GRCh38/hg38
XM_017022411.2 chr15:g.66435229_66435234delGCCAGA c.283_288delGCCAGA p.A95_R96delAR RefSeq GRCh38/hg38
XM_017022411 chr15:g.66435229_66435234delGCCAGA c.283_288delGCCAGA p.A95_R96delAR RefSeq GRCh38/hg38
XM_017022412 chr15:g.66436803_66436808delGTTCTG c.283_288delGTTCTG p.V95_L96delVL RefSeq GRCh38/hg38
XM_017022413.1 chr15:g.66485110_66485115delGAGCTG c.286_291delGAGCTG p.E96_L97delEL RefSeq GRCh38/hg38
NM_002755.4 chr15:g.66435229_66435234delGCCAGA c.283_288delGCCAGA p.A95_R96delAR RefSeq GRCh38/hg38
XM_011521783 chr15:g.66436803_66436808delGTTCTG c.283_288delGTTCTG p.V95_L96delVL RefSeq GRCh38/hg38
NM_001411065.1 chr15:g.66436803_66436808delGTTCTG c.283_288delGTTCTG p.V95_L96delVL RefSeq GRCh38/hg38
NM_002755 chr15:g.66435229_66435234delGCCAGA c.283_288delGCCAGA p.A95_R96delAR RefSeq GRCh38/hg38
XM_011521783.3 chr15:g.66436803_66436808delGTTCTG c.283_288delGTTCTG p.V95_L96delVL RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
MAP2K1 A95_R96del no effect - predicted