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Gene MAP2K1
Variant P105_I107delinsL
Impact List indel
Protein Effect gain of function - predicted
Gene Variant Descriptions MAP2K1 P105_I107delinsL results in the deletion of three amino acids in the protein kinase domain of the Map2k1 protein from amino acids 105 to 107, combined with the insertion of a leucine (L) at the same site (UniProt.org). P105_I107delinsL results in increased Erk phosphorylation in cultured cells (PMID: 32641410), and therefore, is predicted to lead to a gain of Map2k1 protein function.
Associated Drug Resistance
Category Variants Paths

MAP2K1 mutant MAP2K1 act mut MAP2K1 P105_I107delinsL

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Transcript NM_002755.4
gDNA chr15:g.66436768_66436773delCCGCAA
cDNA c.314_319delCCGCAA
Protein p.P105_I107delinsL
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002755 chr15:g.66436768_66436773delCCGCAA c.314_319delCCGCAA p.P105_I107delinsL RefSeq GRCh38/hg38
XM_017022411.2 chr15:g.66436768_66436773delCCGCAA c.314_319delCCGCAA p.P105_I107delinsL RefSeq GRCh38/hg38
NM_002755.3 chr15:g.66436768_66436773delCCGCAA c.314_319delCCGCAA p.P105_I107delinsL RefSeq GRCh38/hg38
XM_017022411 chr15:g.66436768_66436773delCCGCAA c.314_319delCCGCAA p.P105_I107delinsL RefSeq GRCh38/hg38
XM_017022411.3 chr15:g.66436768_66436773delCCGCAA c.314_319delCCGCAA p.P105_I107delinsL RefSeq GRCh38/hg38
NM_002755.4 chr15:g.66436768_66436773delCCGCAA c.314_319delCCGCAA p.P105_I107delinsL RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
MAP2K1 P105_I107delinsL Advanced Solid Tumor decreased response Trametinib Preclinical - Biochemical Actionable In a preclinical study, transformed cells expressing MAP2K1 P105_I107delinsL were less sensitive to Mekinist (trametinib) compared to similar mutations in the negative regulatory domain of the Map2k1 protein in culture (PMID: 32641410). 32641410
MAP2K1 P105_I107delinsL Advanced Solid Tumor predicted - sensitive SCH772984 Preclinical - Biochemical Actionable In a preclinical study, SCH772984 inhibited downstream signaling in transformed cells expressing MAP2K1 P105_I107delinsL in culture (PMID: 32641410). 32641410