We’re improving your experience!

×

Starting April 21, you’ll be asked to log in or sign up for a free account after viewing 10 content pages each month.

Don’t worry—creating an account is quick and easy, and it comes with added benefits! Once logged in, you’ll not only continue accessing the content you already enjoy, but you’ll also unlock exclusive features like interactive donut plots for variant protein effects and variant impacts across the gene.

Stay tuned for these updates, and thank you for being part of our community!

MAP2K1 Q110_I111del - Gene Variant Detail

Request Content

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene MAP2K1
Variant Q110_I111del
Impact List deletion
Protein Effect gain of function - predicted
Gene Variant Descriptions MAP2K1 Q110_I111del results in the deletion of two amino acids in the protein kinase domain of the Map2k1 protein from amino acids 110 to 111 (UniProt.org). Q110_I111del results in increased Erk phosphorylation in cultured cells (PMID: 32641410), and therefore, is predicted to lead to a gain of Map2k1 protein function.
Associated Drug Resistance
Category Variants Paths

MAP2K1 mutant MAP2K1 act mut MAP2K1 Q110_I111del

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_002755.4
gDNA chr15:g.66436782_66436787delCAGATC
cDNA c.328_333delCAGATC
Protein p.Q110_I111delQI
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011521783 chr15:g.66436848_66436853delGCGTTC c.328_333delGCGTTC p.A110_F111delAF RefSeq GRCh38/hg38
XM_017022412.1 chr15:g.66436848_66436853delGCGTTC c.328_333delGCGTTC p.A110_F111delAF RefSeq GRCh38/hg38
NM_002755.3 chr15:g.66436782_66436787delCAGATC c.328_333delCAGATC p.Q110_I111delQI RefSeq GRCh38/hg38
XM_017022411.3 chr15:g.66436782_66436787delCAGATC c.328_333delCAGATC p.Q110_I111delQI RefSeq GRCh38/hg38
XM_017022413 chr15:g.66485152_66485157delACCCCA c.328_333delACCCCA p.T110_P111delTP RefSeq GRCh38/hg38
XM_017022411.2 chr15:g.66436782_66436787delCAGATC c.328_333delCAGATC p.Q110_I111delQI RefSeq GRCh38/hg38
XM_011521783.4 chr15:g.66436848_66436853delGCGTTC c.328_333delGCGTTC p.A110_F111delAF RefSeq GRCh38/hg38
NM_002755 chr15:g.66436782_66436787delCAGATC c.328_333delCAGATC p.Q110_I111delQI RefSeq GRCh38/hg38
XM_011521783.3 chr15:g.66436848_66436853delGCGTTC c.328_333delGCGTTC p.A110_F111delAF RefSeq GRCh38/hg38
NM_001411065.1 chr15:g.66436848_66436853delGCGTTC c.328_333delGCGTTC p.A110_F111delAF RefSeq GRCh38/hg38
XM_017022412 chr15:g.66436848_66436853delGCGTTC c.328_333delGCGTTC p.A110_F111delAF RefSeq GRCh38/hg38
XM_017022411 chr15:g.66436782_66436787delCAGATC c.328_333delCAGATC p.Q110_I111delQI RefSeq GRCh38/hg38
XM_017022413.1 chr15:g.66485152_66485157delACCCCA c.328_333delACCCCA p.T110_P111delTP RefSeq GRCh38/hg38
NM_002755.4 chr15:g.66436782_66436787delCAGATC c.328_333delCAGATC p.Q110_I111delQI RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries