Gene Variant Detail

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Gene MAP2K1
Variant R96_K97del
Impact List deletion
Protein Effect no effect - predicted
Gene Variant Descriptions MAP2K1 R96_K97del results in the deletion of two amino acids in the protein kinase domain of the Map2k1 protein from amino acids 96 to 97 (UniProt.org). R96_K97del induces Erk phosphorylation similar to wild-type Map2k1 in cultured cells (PMID: 32641410), and therefore, is predicted to have no effect on Map2k1 protein function.
Associated Drug Resistance
Category Variants Paths

MAP2K1 mutant MAP2K1 R96_K97del

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Transcript NM_002755.4
gDNA chr15:g.66435232_66435237delAGAAAG
cDNA c.286_291delAGAAAG
Protein p.R96_K97delRK
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002755.4 chr15:g.66435232_66435237delAGAAAG c.286_291delAGAAAG p.R96_K97delRK RefSeq GRCh38/hg38
NM_001411065.1 chr15:g.66436806_66436811delCTGCAT c.286_291delCTGCAT p.L96_H97delLH RefSeq GRCh38/hg38
XM_017022412 chr15:g.66436806_66436811delCTGCAT c.286_291delCTGCAT p.L96_H97delLH RefSeq GRCh38/hg38
XM_011521783.3 chr15:g.66436806_66436811delCTGCAT c.286_291delCTGCAT p.L96_H97delLH RefSeq GRCh38/hg38
XM_017022413.1 chr15:g.66485110_66485115delGAGCTG c.286_291delGAGCTG p.E96_L97delEL RefSeq GRCh38/hg38
XM_011521783.4 chr15:g.66436806_66436811delCTGCAT c.286_291delCTGCAT p.L96_H97delLH RefSeq GRCh38/hg38
XM_017022411.2 chr15:g.66435232_66435237delAGAAAG c.286_291delAGAAAG p.R96_K97delRK RefSeq GRCh38/hg38
XM_011521783 chr15:g.66436806_66436811delCTGCAT c.286_291delCTGCAT p.L96_H97delLH RefSeq GRCh38/hg38
XM_017022411 chr15:g.66435232_66435237delAGAAAG c.286_291delAGAAAG p.R96_K97delRK RefSeq GRCh38/hg38
XM_017022413 chr15:g.66485110_66485115delGAGCTG c.286_291delGAGCTG p.E96_L97delEL RefSeq GRCh38/hg38
XM_017022412.1 chr15:g.66436806_66436811delCTGCAT c.286_291delCTGCAT p.L96_H97delLH RefSeq GRCh38/hg38
NM_002755 chr15:g.66435232_66435237delAGAAAG c.286_291delAGAAAG p.R96_K97delRK RefSeq GRCh38/hg38
NM_002755.3 chr15:g.66435232_66435237delAGAAAG c.286_291delAGAAAG p.R96_K97delRK RefSeq GRCh38/hg38
XM_017022411.3 chr15:g.66435232_66435237delAGAAAG c.286_291delAGAAAG p.R96_K97delRK RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References