PIK3CA E418K
Gene Variant Detail

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Gene PIK3CA
Variant E418K
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions PIK3CA E418K lies within the C2 PI3K-type domain of the Pik3ca protein (UniProt.org). E418K does not increase proliferation in cultured cells in one study (PMID: 38909932), but results in increased cell growth compared to wild-type PIK3CA in multiple cell lines in another study (PMID: 34779417), leads to increased Akt phosphorylation, migration (PMID: 38909932, PMID: 34779417), and invasion (PMID: 38909932), and demonstrates transforming activity in cultured cells (PMID: 34779417).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA act mut PIK3CA E418K

PIK3CA mutant PIK3CA exon8 PIK3CA E418K

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Transcript NM_006218.4
gDNA chr3:g.179210186G>A
cDNA c.1252G>A
Protein p.E418K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006713658 chr3:g.179210186G>A c.1252G>A p.E418K RefSeq GRCh38/hg38
XM_011512894 chr3:g.179210186G>A c.1252G>A p.E418K RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179210186G>A c.1252G>A p.E418K RefSeq GRCh38/hg38
NM_006218 chr3:g.179210186G>A c.1252G>A p.E418K RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179210186G>A c.1252G>A p.E418K RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179210186G>A c.1252G>A p.E418K RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179210186G>A c.1252G>A p.E418K RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179210186G>A c.1252G>A p.E418K RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PIK3CA E418K breast cancer sensitive LY294002 Preclinical - Cell culture Actionable In a preclinical study, LY294002 inhibited proliferation of a breast cancer cell line expressing PIK3CA E418K in culture (PMID: 38909932). 38909932