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| Profile Name | PIK3CA E418K |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| PIK3CA E418K | breast cancer | sensitive | LY294002 | Preclinical - Cell culture | Actionable | In a preclinical study, LY294002 inhibited proliferation of a breast cancer cell line expressing PIK3CA E418K in culture (PMID: 38909932). | 38909932 |