AXL Y779F
Gene Variant Detail

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Gene AXL
Variant Y779F
Impact List missense
Protein Effect unknown
Gene Variant Descriptions AXL Y779F lies within the protein kinase domain of the Axl protein (UniProt.org). Y779F demonstrates similar binding to Abl2 in the presence of ligand in cell culture (PMID: 31825826) and confers resistance Erbitux (cetuximab) in cell culture (PMID: 32439698), but has not been fully biochemically characterized and therefore, its effect on Axl protein function is unknown.
Associated Drug Resistance Y
Category Variants Paths

AXL mutant AXL Y779F

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Transcript NM_021913.5
gDNA chr19:g.41259555A>T
cDNA c.2336A>T
Protein p.Y779F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_021913.5 chr19:g.41259555A>T c.2336A>T p.Y779F RefSeq GRCh38/hg38
NM_021913.4 chr19:g.41259555A>T c.2336A>T p.Y779F RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
AXL Y779F head and neck squamous cell carcinoma resistant Cetuximab Preclinical - Cell culture Actionable In a preclinical study, Erbitux (cetuximab) treatment did not inhibit proliferation of head and neck squamous cell carcinoma cells expressing AXL Y779F in culture (PMID: 32439698). 32439698