AXL Y821F
Gene Variant Detail

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Gene AXL
Variant Y821F
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions AXL Y821F lies within the protein kinase domain of the Axl protein (PMID: 31825826). Y821F demonstrates reduced binding to Abl2 in the presence of ligand in cell culture (PMID: 31825826), and therefore, is predicted to lead to a loss of Axl protein function.
Associated Drug Resistance
Category Variants Paths

AXL mutant AXL inact mut AXL Y821F

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Transcript NM_021913.5
gDNA chr19:g.41259681A>T
cDNA c.2462A>T
Protein p.Y821F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001699.6 chr19:g.41259708A>T c.2462A>T p.Y821F RefSeq GRCh38/hg38
NM_021913.4 chr19:g.41259681A>T c.2462A>T p.Y821F RefSeq GRCh38/hg38
NM_021913.5 chr19:g.41259681A>T c.2462A>T p.Y821F RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries