AXL Y866F
Gene Variant Detail

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Gene AXL
Variant Y866F
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions AXL Y866F lies within the cytoplasmic domain of the Axl protein (UniProt.org). Y866F has been demonstrated to confer resistance to Egfr inhibitors in culture (PMID: 32439698), but demonstrates similar binding to Abl2 in the presence of ligand (PMID: 31825826), and does not induce cellular transformation in culture (PMID: 9671397), and therefore, is predicted to have no effect on Axl protein function.
Associated Drug Resistance Y
Category Variants Paths

AXL mutant AXL Y866F

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Transcript NM_021913.5
gDNA chr19:g.41259816A>T
cDNA c.2597A>T
Protein p.Y866F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_021913.4 chr19:g.41259816A>T c.2597A>T p.Y866F RefSeq GRCh38/hg38
NM_021913.5 chr19:g.41259816A>T c.2597A>T p.Y866F RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
AXL Y866F head and neck squamous cell carcinoma resistant Cetuximab Preclinical - Cell culture Actionable In a preclinical study, Erbitux (cetuximab) treatment did not inhibit proliferation of head and neck squamous cell carcinoma cells expressing AXL Y866F in culture (PMID: 32439698). 32439698