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Gene RET
Variant V648I
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET V648I lies within the transmembrane domain of the Ret protein (UniProt.org). V648I results in increased cell proliferation, but is not transforming in cell culture (PMID: 21810974), and therefore, its effect on Ret protein function is unknown.
Associated Drug Resistance
Category Variants Paths

RET mutant RET V648I

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Transcript NM_020975.6
gDNA chr10:g.43114542G>A
cDNA c.1942G>A
Protein p.V648I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406743.1 chr10:g.43114542G>A c.1942G>A p.V648I RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43114542G>A c.1942G>A p.V648I RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43114542G>A c.1942G>A p.V648I RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43114542G>A c.1942G>A p.V648I RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43114542G>A c.1942G>A p.V648I RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43114542G>A c.1942G>A p.V648I RefSeq GRCh38/hg38
NM_020975 chr10:g.43114542G>A c.1942G>A p.V648I RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43114542G>A c.1942G>A p.V648I RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43114542G>A c.1942G>A p.V648I RefSeq GRCh38/hg38
NM_020630 chr10:g.43114542G>A c.1942G>A p.V648I RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References