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Gene BRAF
Variant A404Cfs*9
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions BRAF A404Cfs*9 indicates a shift in the reading frame starting at amino acid 404 and terminating 9 residues downstream causing a premature truncation of the 766 amino acid Braf protein (UniProt.org). Due to the loss of the protein kinase domain (UniProt.org), A404Cfs*9 is predicted to lead to a loss of Braf protein function.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF inact mut BRAF A404Cfs*9

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Transcript NM_004333.6
gDNA chr7:g.140783126dupA
cDNA c.1209dupT
Protein p.A404Cfs*9
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001378474.1 chr7:g.140783126dupA c.1209dupT p.A404Cfs*9 RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140783126dupA c.1209dupT p.A404Cfs*9 RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.140783126dupA c.1209dupT p.A404Cfs*9 RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140783126dupA c.1209dupT p.A404Cfs*9 RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140783126dupA c.1209dupT p.A404Cfs*9 RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140783126dupA c.1209dupT p.A404Cfs*9 RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140783126dupA c.1209dupT p.A404Cfs*9 RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
BRAF A404Cfs*9 loss of function - predicted