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Gene RET
Variant R873W
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET R873W lies within the protein kinase domain of the Ret protein (UniProt.org). R873W has been identified in sequencing studies (PMID: 27998968, PMID: 22622578, PMID: 22722839), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Feb 2024).
Associated Drug Resistance
Category Variants Paths

RET mutant RET R873W

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Transcript NM_020975.6
gDNA chr10:g.43120090C>T
cDNA c.2617C>T
Protein p.R873W
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406759.1 chr10:g.43120090C>T c.2617C>T p.R873W RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43120090C>T c.2617C>T p.R873W RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43120090C>T c.2617C>T p.R873W RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43120090C>T c.2617C>T p.R873W RefSeq GRCh38/hg38
NM_001406766.1 chr10:g.43123774C>T c.2617C>T p.R873W RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43120090C>T c.2617C>T p.R873W RefSeq GRCh38/hg38
NM_001406767.1 chr10:g.43123774C>T c.2617C>T p.R873W RefSeq GRCh38/hg38
NM_020975 chr10:g.43120090C>T c.2617C>T p.R873W RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43120090C>T c.2617C>T p.R873W RefSeq GRCh38/hg38
NM_001406770.1 chr10:g.43123774C>T c.2617C>T p.R873W RefSeq GRCh38/hg38
NM_020630 chr10:g.43120090C>T c.2617C>T p.R873W RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43120090C>T c.2617C>T p.R873W RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43120090C>T c.2617C>T p.R873W RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References