Gene Variant Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene RET
Variant M980T
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions RET M980T lies within the protein kinase domain of the Ret protein (UniProt.org). M980T results in decreased ligand-dependent phosphorylation of Ret and downstream signaling molecules including PLCgamma, Shc, and Erk in culture (PMID: 11438491).
Associated Drug Resistance
Category Variants Paths

RET mutant RET inact mut RET M980T

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_020975.6
gDNA chr10:g.43123808T>C
cDNA c.2939T>C
Protein p.M980T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020975.6 chr10:g.43123808T>C c.2939T>C p.M980T RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43123808T>C c.2939T>C p.M980T RefSeq GRCh38/hg38
NM_020975 chr10:g.43123808T>C c.2939T>C p.M980T RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43123808T>C c.2939T>C p.M980T RefSeq GRCh38/hg38
NM_020630 chr10:g.43123808T>C c.2939T>C p.M980T RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43123808T>C c.2939T>C p.M980T RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43123808T>C c.2939T>C p.M980T RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43123808T>C c.2939T>C p.M980T RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43123808T>C c.2939T>C p.M980T RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43123808T>C c.2939T>C p.M980T RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References