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Gene RET
Variant M980T
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions RET M980T lies within the protein kinase domain of the Ret protein (UniProt.org). M980T results in decreased ligand-dependent phosphorylation of Ret and downstream signaling molecules including PLCgamma, Shc, and Erk in culture (PMID: 11438491).
Associated Drug Resistance
Category Variants Paths

RET mutant RET inact mut RET M980T

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Transcript NM_020975.6
gDNA chr10:g.43123808T>C
cDNA c.2939T>C
Protein p.M980T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406743.1 chr10:g.43123808T>C c.2939T>C p.M980T RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43123808T>C c.2939T>C p.M980T RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43123808T>C c.2939T>C p.M980T RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43123808T>C c.2939T>C p.M980T RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43123808T>C c.2939T>C p.M980T RefSeq GRCh38/hg38
NM_020975 chr10:g.43123808T>C c.2939T>C p.M980T RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43123808T>C c.2939T>C p.M980T RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43123808T>C c.2939T>C p.M980T RefSeq GRCh38/hg38
NM_020630 chr10:g.43123808T>C c.2939T>C p.M980T RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43123808T>C c.2939T>C p.M980T RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries