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Gene ABL1
Variant A337T
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions ABL1 A337T lies within the protein kinase domain of the Abl1 protein (UniProt.org). A337T confers a gain of function to the Abl1 protein as demonstrated by increased phosphorylation of STAT5 and ABL1 and elevated total phosphotyrosine levels in cultured cells (PMID: 28288113).
Associated Drug Resistance
Category Variants Paths

ABL1 mutant ABL1 act mut ABL1 A337T

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Transcript NM_005157.6
gDNA chr9:g.130872961G>A
cDNA c.1009G>A
Protein p.A337T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_005157.5 chr9:g.130872961G>A c.1009G>A p.A337T RefSeq GRCh38/hg38
NM_005157.6 chr9:g.130872961G>A c.1009G>A p.A337T RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References