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Gene RET
Variant A919V
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET A919V lies within the protein kinase domain of the Ret protein (UniProt.org). A919V is predicted to result in decreased Ret protein stability in computational models (PMID: 16928683, PMID: 19186126), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Jun 2024).
Associated Drug Resistance
Category Variants Paths

RET mutant RET A919V

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Transcript NM_020975.6
gDNA chr10:g.43121971C>T
cDNA c.2756C>T
Protein p.A919V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020975 chr10:g.43121971C>T c.2756C>T p.A919V RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43121971C>T c.2756C>T p.A919V RefSeq GRCh38/hg38
NM_001406769.1 chr10:g.43126687C>T c.2756C>T p.A919V RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43121971C>T c.2756C>T p.A919V RefSeq GRCh38/hg38
NM_020630 chr10:g.43121971C>T c.2756C>T p.A919V RefSeq GRCh38/hg38
NM_001406772.1 chr10:g.43126687C>T c.2756C>T p.A919V RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43121971C>T c.2756C>T p.A919V RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43121971C>T c.2756C>T p.A919V RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43121971C>T c.2756C>T p.A919V RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43121971C>T c.2756C>T p.A919V RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43121971C>T c.2756C>T p.A919V RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43121971C>T c.2756C>T p.A919V RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Sorting

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Molecular Profile Protein Effect Treatment Approaches
RET A919V unknown