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Gene RET
Variant E623K
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET E623K lies within the extracellular domain of the Ret protein (UniProt.org). E623K has been identified in the scientific literature (PMID: 16849421, PMID: 15858153), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Feb 2024).
Associated Drug Resistance
Category Variants Paths

RET mutant RET E623K

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Transcript NM_020975.6
gDNA chr10:g.43113663G>A
cDNA c.1867G>A
Protein p.E623K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406759.1 chr10:g.43113663G>A c.1867G>A p.E623K RefSeq GRCh38/hg38
NM_001406791.1 chr10:g.43126707G>A c.1867G>A p.E623K RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43113663G>A c.1867G>A p.E623K RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43113663G>A c.1867G>A p.E623K RefSeq GRCh38/hg38
NM_001406765.1 chr10:g.43113663G>A c.1867G>A p.E623K RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43113663G>A c.1867G>A p.E623K RefSeq GRCh38/hg38
NM_020975 chr10:g.43113663G>A c.1867G>A p.E623K RefSeq GRCh38/hg38
NM_020630 chr10:g.43113663G>A c.1867G>A p.E623K RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43113663G>A c.1867G>A p.E623K RefSeq GRCh38/hg38
NM_001406763.1 chr10:g.43113663G>A c.1867G>A p.E623K RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43113663G>A c.1867G>A p.E623K RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43113663G>A c.1867G>A p.E623K RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43113663G>A c.1867G>A p.E623K RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References