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Gene RET
Variant F612_C620del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions RET F612_C620del results in the deletion of nine amino acids in the extracellular domain of the Ret protein from amino acids 612 to 620 (UniProt.org). F612_C620del has been identified in sequencing studies (PMID: 25157968, PMID: 9587071), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Apr 2024).
Associated Drug Resistance
Category Variants Paths

RET mutant RET F612_C620del

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Transcript NM_020975.6
gDNA chr10:g.43113630_43113656del27
cDNA c.1834_1860del27
Protein p.F612_C620delFPEEEKCFC
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406781.1 chr10:g.43121946_43121972del27 c.1834_1860del27 p.G612_A620delGRIPVKWMA RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43113630_43113656del27 c.1834_1860del27 p.F612_C620del RefSeq GRCh38/hg38
NM_001406791.1 chr10:g.43126674_43126700del27 c.1834_1860del27 p.P612_T620delPLPRALPST RefSeq GRCh38/hg38
NM_001406787.1 chr10:g.43123735_43123761del27 c.1834_1860del27 p.P612_L620delPPERLFNLL RefSeq GRCh38/hg38
NM_001406780.1 chr10:g.43121946_43121972del27 c.1834_1860del27 p.G612_A620delGRIPVKWMA RefSeq GRCh38/hg38
NM_001406782.1 chr10:g.43121946_43121972del27 c.1834_1860del27 p.G612_A620delGRIPVKWMA RefSeq GRCh38/hg38
NM_001406768.1 chr10:g.43114698_43114724del27 c.1834_1860del27 p.M612_A620delMENQVSVDA RefSeq GRCh38/hg38
NM_001406762.1 chr10:g.43114563_43114589del27 c.1834_1860del27 p.F612_F620delFCIHCYHKF RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43113630_43113656del27 c.1834_1860del27 p.F612_C620delFPEEEKCFC RefSeq GRCh38/hg38
NM_001406776.1 chr10:g.43119698_43119724del27 c.1834_1860del27 p.F612_M620delFAWQISQGM RefSeq GRCh38/hg38
NM_001406773.1 chr10:g.43116720_43118387del1668 c.1835_1861del1668 p.K612_P620delKMLKENASP RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43113630_43113656del27 c.1834_1860del27 p.F612_C620delFPEEEKCFC RefSeq GRCh38/hg38
NM_001406771.1 chr10:g.43116720_43118387del1668 c.1835_1861del1668 p.K612_P620delKMLKENASP RefSeq GRCh38/hg38
NM_001406770.1 chr10:g.43114722_43116595del1874 c.1834_1860del1874 p.A612_K620delAFKILEDPK RefSeq GRCh38/hg38
NM_001406785.1 chr10:g.43123721_43123747del27 c.1835_1861del27 p.P612_R620delPYPGIPPER RefSeq GRCh38/hg38
NM_001406792.1 chr10:g.43128207_43128233del27 c.1834_1860del27 p.V612_P620delVYANWMLSP RefSeq GRCh38/hg38
NM_001406790.1 chr10:g.43124962_43126580del1619 c.1834_1860del1619 p.K612_Y620delKMMVKRRDY RefSeq GRCh38/hg38
NM_001406772.1 chr10:g.43116677_43116703del27 c.1834_1860del27 p.F612_Y620delFHLKGRAGY RefSeq GRCh38/hg38
NM_001406769.1 chr10:g.43116677_43116703del27 c.1834_1860del27 p.F612_Y620delFHLKGRAGY RefSeq GRCh38/hg38
NM_001406766.1 chr10:g.43114722_43116595del1874 c.1834_1860del1874 p.A612_K620delAFKILEDPK RefSeq GRCh38/hg38
NM_001406784.1 chr10:g.43123693_43123719del27 c.1834_1860del27 p.W612_N620delWEIVTLGGN RefSeq GRCh38/hg38
NM_001406777.1 chr10:g.43119698_43119724del27 c.1834_1860del27 p.F612_M620delFAWQISQGM RefSeq GRCh38/hg38
NM_001355216.1 chr10:g.43119734_43120095del362 c.1834_1860del362 p.A612_D620delAEMKLVHRD RefSeq GRCh38/hg38
NM_001406779.1 chr10:g.43121946_43121972del27 c.1834_1860del27 p.G612_A620delGRIPVKWMA RefSeq GRCh38/hg38
NM_001406761.1 chr10:g.43114563_43114589del27 c.1834_1860del27 p.F612_F620delFCIHCYHKF RefSeq GRCh38/hg38
NM_001406774.1 chr10:g.43118447_43118473del27 c.1834_1860del27 p.V612_S620delVIKLYGACS RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43113630_43113656del27 c.1834_1860del27 p.F612_C620delFPEEEKCFC RefSeq GRCh38/hg38
NM_001406767.1 chr10:g.43114722_43116595del1874 c.1834_1860del1874 p.A612_K620delAFKILEDPK RefSeq GRCh38/hg38
NM_001406786.1 chr10:g.43123729_43123755del27 c.1834_1860del27 p.G612_N620delGIPPERLFN RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43113630_43113656del27 c.1834_1860del27 p.F612_C620delFPEEEKCFC RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43113630_43113656del27 c.1834_1860del27 p.F612_C620delFPEEEKCFC RefSeq GRCh38/hg38
NM_001406765.1 chr10:g.43113630_43113656del27 c.1834_1860del27 p.F612_C620delFPEEEKCFC RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43113630_43113656del27 c.1834_1860del27 p.F612_C620delFPEEEKCFC RefSeq GRCh38/hg38
NM_001406763.1 chr10:g.43113630_43113656del27 c.1834_1860del27 p.F612_C620delFPEEEKCFC RefSeq GRCh38/hg38
NM_001406764.1 chr10:g.43114563_43114589del27 c.1834_1860del27 p.F612_F620delFCIHCYHKF RefSeq GRCh38/hg38
NM_001355216.2 chr10:g.43119734_43120095del362 c.1834_1860del362 p.A612_D620delAEMKLVHRD RefSeq GRCh38/hg38
NM_020975 chr10:g.43113630_43113656del27 c.1834_1860del27 p.F612_C620delFPEEEKCFC RefSeq GRCh38/hg38
NM_020630 chr10:g.43113630_43113656del27 c.1834_1860del27 p.F612_C620delFPEEEKCFC RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43113630_43113656del27 c.1834_1860del27 p.F612_C620delFPEEEKCFC RefSeq GRCh38/hg38
NM_001406775.1 chr10:g.43119698_43119724del27 c.1834_1860del27 p.F612_M620delFAWQISQGM RefSeq GRCh38/hg38
NM_001406778.1 chr10:g.43119698_43119724del27 c.1834_1860del27 p.F612_M620delFAWQISQGM RefSeq GRCh38/hg38
NM_001406788.1 chr10:g.43124962_43126580del1619 c.1834_1860del1619 p.K612_Y620delKMMVKRRDY RefSeq GRCh38/hg38
NM_001406789.1 chr10:g.43124962_43126580del1619 c.1834_1860del1619 p.K612_Y620delKMMVKRRDY RefSeq GRCh38/hg38
NM_001406783.1 chr10:g.43123729_43123755del27 c.1834_1860del27 p.G612_N620delGIPPERLFN RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References