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Gene RET
Variant E768D
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions RET E768D lies within the protein kinase domain of the Ret protein (UniProt.org). E768D results in increased Ret autophosphorylation and is transforming in cell culture (PMID: 10445857).
Associated Drug Resistance
Category Variants Paths

RET mutant RET act mut RET E768D

RET mutant RET E768X RET E768D

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Transcript NM_020975.6
gDNA chr10:g.43118392G>C
cDNA c.2304G>C
Protein p.E768D
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406759.1 chr10:g.43118392G>C c.2304G>C p.E768D RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43118392G>C c.2304G>C p.E768D RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43118392G>C c.2304G>C p.E768D RefSeq GRCh38/hg38
NM_020975 chr10:g.43118392G>C c.2304G>C p.E768D RefSeq GRCh38/hg38
NM_020630 chr10:g.43118392G>C c.2304G>C p.E768D RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43118392G>C c.2304G>C p.E768D RefSeq GRCh38/hg38
NM_001406774.1 chr10:g.43123698G>C c.2304G>C p.E768D RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43118392G>C c.2304G>C p.E768D RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43118392G>C c.2304G>C p.E768D RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43118392G>C c.2304G>C p.E768D RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43118392G>C c.2304G>C p.E768D RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET E768D Advanced Solid Tumor sensitive Ponatinib Preclinical Actionable In a preclinical study, Iclusig (ponatinib) inhibited phosphorylation of Ret in transformed human cells expressing RET E768D in culture (PMID: 23526464). 23526464
RET E768D Advanced Solid Tumor sensitive Vandetanib Preclinical Actionable In a preclinical study, Caprelsa (vandetanib) inhibited Ret autophosphorylation in transformed cells expressing RET E768D in culture (PMID: 15184865). 15184865