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Gene RET
Variant E768D
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions RET E768D lies within the protein kinase domain of the Ret protein (UniProt.org). E768D results in increased Ret autophosphorylation and is transforming in cell culture (PMID: 10445857).
Associated Drug Resistance
Category Variants Paths

RET mutant RET act mut RET E768D

RET mutant RET E768X RET E768D

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Transcript NM_020975.6
gDNA chr10:g.43118392G>C
cDNA c.2304G>C
Protein p.E768D
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020975 chr10:g.43118392G>C c.2304G>C p.E768D RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43118392G>C c.2304G>C p.E768D RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43118392G>C c.2304G>C p.E768D RefSeq GRCh38/hg38
NM_020630 chr10:g.43118392G>C c.2304G>C p.E768D RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43118392G>C c.2304G>C p.E768D RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43118392G>C c.2304G>C p.E768D RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43118392G>C c.2304G>C p.E768D RefSeq GRCh38/hg38
NM_001406774.1 chr10:g.43123698G>C c.2304G>C p.E768D RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43118392G>C c.2304G>C p.E768D RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43118392G>C c.2304G>C p.E768D RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43118392G>C c.2304G>C p.E768D RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Protein Effect Treatment Approaches
RET E768D gain of function RET Inhibitor