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Gene RET
Variant S765P
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions RET S765P lies within the protein kinase domain of the Ret protein (UniProt.org). S765P results in a loss of ligand-dependent phosphorylation of Ret and downstream signaling molecules including Erk, Akt, and PLCgamma, is not transforming in culture, and abolishes the activity of a concurrent activating IDH1 mutation (C634R) in culture (PMID: 11438491).
Associated Drug Resistance
Category Variants Paths

RET mutant RET inact mut RET S765P

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Transcript NM_020975.6
gDNA chr10:g.43118381T>C
cDNA c.2293T>C
Protein p.S765P
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020630.7 chr10:g.43118381T>C c.2293T>C p.S765P RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43118381T>C c.2293T>C p.S765P RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43118381T>C c.2293T>C p.S765P RefSeq GRCh38/hg38
NM_020630 chr10:g.43118381T>C c.2293T>C p.S765P RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43118381T>C c.2293T>C p.S765P RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43118381T>C c.2293T>C p.S765P RefSeq GRCh38/hg38
NM_001406768.1 chr10:g.43119695T>C c.2293T>C p.S765P RefSeq GRCh38/hg38
NM_020975 chr10:g.43118381T>C c.2293T>C p.S765P RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43118381T>C c.2293T>C p.S765P RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43118381T>C c.2293T>C p.S765P RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43118381T>C c.2293T>C p.S765P RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
RET S765P loss of function