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Gene ABL1
Variant T315V
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ABL1 T315V lies within the protein kinase domain of the Abl1 protein (UniProt.org). T315V has been demonstrated to occur as a secondary resistance mutation in the context of BCR-ABL1 (PMID: 23044928), but has not been biochemically characterized and therefore, its effect on Abl1 protein function is unknown (PubMed, Aug 2024).
Associated Drug Resistance Y
Category Variants Paths

ABL1 mutant ABL1 T315V

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Transcript NM_005157.6
gDNA chr9:g.130872895_130872896delACinsGT
cDNA c.943_944delACinsGT
Protein p.T315V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_005157.5 chr9:g.130872895_130872896delACinsGT c.943_944delACinsGT p.T315V RefSeq GRCh38/hg38
NM_005157.6 chr9:g.130872895_130872896delACinsGT c.943_944delACinsGT p.T315V RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References