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| Gene | RET |
| Variant | V706M |
| Impact List | missense |
| Protein Effect | unknown |
| Gene Variant Descriptions | RET V706M lies within the cytoplasmic domain of the Ret protein (UniProt.org). V706M has been identified in sequencing studies (PMID: 27683183, PMID: 30446652, PMID: 34741450), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Nov 2025). |
| Associated Drug Resistance | |
| Category Variants Paths |
RET mutant RET V706M |
| Transcript | NM_020975.6 |
| gDNA | chr10:g.43114716G>A |
| cDNA | c.2116G>A |
| Protein | p.V706M |
| Source Database | RefSeq |
| Genome Build | GRCh38/hg38 |
| Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
|---|---|---|---|---|---|
| NM_001406759.1 | chr10:g.43114716G>A | c.2116G>A | p.V706M | RefSeq | GRCh38/hg38 |
| NM_020630.7 | chr10:g.43114716G>A | c.2116G>A | p.V706M | RefSeq | GRCh38/hg38 |
| NM_020975.5 | chr10:g.43114716G>A | c.2116G>A | p.V706M | RefSeq | GRCh38/hg38 |
| NM_001406743.1 | chr10:g.43114716G>A | c.2116G>A | p.V706M | RefSeq | GRCh38/hg38 |
| NM_001406760.1 | chr10:g.43114716G>A | c.2116G>A | p.V706M | RefSeq | GRCh38/hg38 |
| NM_020630.5 | chr10:g.43114716G>A | c.2116G>A | p.V706M | RefSeq | GRCh38/hg38 |
| NM_020975.6 | chr10:g.43114716G>A | c.2116G>A | p.V706M | RefSeq | GRCh38/hg38 |
| NM_001406744.1 | chr10:g.43114716G>A | c.2116G>A | p.V706M | RefSeq | GRCh38/hg38 |
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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