Gene Variant Detail

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Gene RET
Variant R969Q
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET R969Q lies within the protein kinase domain of the Ret protein (UniProt.org). R969Q has been identified in sequencing studies (PMID: 27149842), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Feb 2024).
Associated Drug Resistance
Category Variants Paths

RET mutant RET R969Q

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Transcript NM_020975.6
gDNA chr10:g.43123775G>A
cDNA c.2906G>A
Protein p.R969Q
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020630.5 chr10:g.43123775G>A c.2906G>A p.R969Q RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43123775G>A c.2906G>A p.R969Q RefSeq GRCh38/hg38
NM_001406764.1 chr10:g.43124977_43124978delAGinsCA c.2905_2906delAGinsCA p.R969Q RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43123775G>A c.2906G>A p.R969Q RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43123775G>A c.2906G>A p.R969Q RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43123775G>A c.2906G>A p.R969Q RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43123775G>A c.2906G>A p.R969Q RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43123775G>A c.2906G>A p.R969Q RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43123775G>A c.2906G>A p.R969Q RefSeq GRCh38/hg38
NM_001406762.1 chr10:g.43124977_43124978delAGinsCA c.2905_2906delAGinsCA p.R969Q RefSeq GRCh38/hg38
NM_001406761.1 chr10:g.43124977_43124978delAGinsCA c.2905_2906delAGinsCA p.R969Q RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References