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Gene RET
Variant P841L
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET P841L lies within the protein kinase domain of the Ret protein (UniProt.org). P841L has been identified in sequencing studies (PMID: 27149842), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Feb 2024).
Associated Drug Resistance
Category Variants Paths

RET mutant RET P841L

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Transcript NM_020975.6
gDNA chr10:g.43119660C>T
cDNA c.2522C>T
Protein p.P841L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406760.1 chr10:g.43119660C>T c.2522C>T p.P841L RefSeq GRCh38/hg38
NM_001406769.1 chr10:g.43123787C>T c.2522C>T p.P841L RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43119660C>T c.2522C>T p.P841L RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43119660C>T c.2522C>T p.P841L RefSeq GRCh38/hg38
NM_001406772.1 chr10:g.43123787C>T c.2522C>T p.P841L RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43119660C>T c.2522C>T p.P841L RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43119660C>T c.2522C>T p.P841L RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43119660C>T c.2522C>T p.P841L RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43119660C>T c.2522C>T p.P841L RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43119660C>T c.2522C>T p.P841L RefSeq GRCh38/hg38
NM_001406777.1 chr10:g.43128232C>T c.2522C>T p.P841L RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References