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Gene KEAP1
Variant D236V
Impact List missense
Protein Effect no effect
Gene Variant Descriptions KEAP1 D236V lies within the BACK domain of the Keap1 protein (UniProt.org). D236V results in a similar decrease in Nfe2l2 target gene expression and reduction in cell survival following irradiation and hydrogen peroxide treatment to wild-type Keap1 in culture (PMID: 33071215).
Associated Drug Resistance
Category Variants Paths

KEAP1 mutant KEAP1 D236V

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Transcript NM_203500.2
gDNA chr19:g.10492195T>A
cDNA c.707A>T
Protein p.D236V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_203500.1 chr19:g.10492195T>A c.707A>T p.D236V RefSeq GRCh38/hg38
XM_005260174.1 chr19:g.10492195T>A c.707A>T p.D236V RefSeq GRCh38/hg38
NM_012289.3 chr19:g.10492195T>A c.707A>T p.D236V RefSeq GRCh38/hg38
NM_203500.2 chr19:g.10492195T>A c.707A>T p.D236V RefSeq GRCh38/hg38
XM_011528452.1 chr19:g.10492195T>A c.707A>T p.D236V RefSeq GRCh38/hg38
XM_005260173.1 chr19:g.10492195T>A c.707A>T p.D236V RefSeq GRCh38/hg38
NM_012289.4 chr19:g.10492195T>A c.707A>T p.D236V RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References