ERBB4 G863E
Gene Variant Detail

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Gene ERBB4
Variant G863E
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions ERBB4 G863E lies within the protein kinase domain of the Erbb4 protein (UniProt.org). G863E a loss of ligand-dependent phosphorylation of Erbb4 and downstream signaling, reduced ability to promote ligand-dependent cell growth, and is not transforming in culture (PMID: 33323455).
Associated Drug Resistance
Category Variants Paths

ERBB4 mutant ERBB4 inact mut ERBB4 G863E

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Transcript NM_005235.3
gDNA chr2:g.211431000C>T
cDNA c.2588G>A
Protein p.G863E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001042599.1 chr2:g.211431000C>T c.2588G>A p.G863E RefSeq GRCh38/hg38
NM_001042599.1 chr2:g.211431000C>T c.2588G>A p.G863E RefSeq GRCh38/hg38
NM_005235.2 chr2:g.211431000C>T c.2588G>A p.G863E RefSeq GRCh38/hg38
NM_005235.3 chr2:g.211431000C>T c.2588G>A p.G863E RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
ERBB4 G863E loss of function