Gene Variant Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene CTNNB1
Variant S37F
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions CTNNB1 S37F lies within the ubiquitination recognition motif of the Ctnnb1 protein and occurs at a Gsk3b phosphorylation site on the Ctnnb1 protein (PMID: 10347231). S37F confers a gain of function to the Ctnnb1 protein as demonstrated by nuclear accumulation of Ctnnb1 (PMID: 11196159, PMID: 11943721), increased activity in a reporter assay (PMID: 31857074), and increased cell invasion and migration in the context of an EGFR activating mutation (PMID: 29106415).
Associated Drug Resistance
Category Variants Paths

CTNNB1 mutant CTNNB1 act mut CTNNB1 S37F

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_001098210.2
gDNA chr3:g.41224622C>T
cDNA c.110C>T
Protein p.S37F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_047447483.1 chr3:g.41224622C>T c.110C>T p.S37F RefSeq GRCh38/hg38
XM_047447478.1 chr3:g.41224622C>T c.110C>T p.S37F RefSeq GRCh38/hg38
NM_001904.4 chr3:g.41224622C>T c.110C>T p.S37F RefSeq GRCh38/hg38
XM_006712985.1 chr3:g.41224622C>T c.110C>T p.S37F RefSeq GRCh38/hg38
XM_024453356.2 chr3:g.41224622C>T c.110C>T p.S37F RefSeq GRCh38/hg38
XM_006712985 chr3:g.41224622C>T c.110C>T p.S37F RefSeq GRCh38/hg38
NM_001098210.1 chr3:g.41224622C>T c.110C>T p.S37F RefSeq GRCh38/hg38
NM_001098210.2 chr3:g.41224622C>T c.110C>T p.S37F RefSeq GRCh38/hg38
XM_017005738.1 chr3:g.41224622C>T c.110C>T p.S37F RefSeq GRCh38/hg38
XM_047447480.1 chr3:g.41224622C>T c.110C>T p.S37F RefSeq GRCh38/hg38
XM_024453356.1 chr3:g.41224622C>T c.110C>T p.S37F RefSeq GRCh38/hg38
XM_047447481.1 chr3:g.41224622C>T c.110C>T p.S37F RefSeq GRCh38/hg38
NM_001098209.1 chr3:g.41224622C>T c.110C>T p.S37F RefSeq GRCh38/hg38
XM_047447477.1 chr3:g.41224622C>T c.110C>T p.S37F RefSeq GRCh38/hg38
XM_005264886 chr3:g.41224622C>T c.110C>T p.S37F RefSeq GRCh38/hg38
XM_017005738 chr3:g.41224622C>T c.110C>T p.S37F RefSeq GRCh38/hg38
NM_001904.3 chr3:g.41224622C>T c.110C>T p.S37F RefSeq GRCh38/hg38
NM_001098209 chr3:g.41224622C>T c.110C>T p.S37F RefSeq GRCh38/hg38
NM_001904 chr3:g.41224622C>T c.110C>T p.S37F RefSeq GRCh38/hg38
XM_047447479.1 chr3:g.41224622C>T c.110C>T p.S37F RefSeq GRCh38/hg38
XM_024453358.1 chr3:g.41224622C>T c.110C>T p.S37F RefSeq GRCh38/hg38
XM_006712985.2 chr3:g.41224622C>T c.110C>T p.S37F RefSeq GRCh38/hg38
XM_024453357.1 chr3:g.41224622C>T c.110C>T p.S37F RefSeq GRCh38/hg38
XM_017005738.2 chr3:g.41224622C>T c.110C>T p.S37F RefSeq GRCh38/hg38
NM_001098210 chr3:g.41224622C>T c.110C>T p.S37F RefSeq GRCh38/hg38
NM_001098209.2 chr3:g.41224622C>T c.110C>T p.S37F RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04851119 Phase Ib/II BC2059 Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors Recruiting USA 0