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Therapy Name Tegavivint
Synonyms
Therapy Description

Tegavivint (BC2059) binds to beta-catenin (CTNNB1) and interferes with binding to TBL1 and TBLR1, resulting in increased degradation of beta-catenin and potentially leading to increased apoptosis of tumor cells with activated canonical Wnt signaling (PMID: 28500235, PMID: 30793158).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Tegavivint BC-2059|BC 2059|Tegatrabetan|BC2059 CTNNB1 Inhibitor 27 Tegavivint (BC2059) binds to beta-catenin (CTNNB1) and interferes with binding to TBL1 and TBLR1, resulting in increased degradation of beta-catenin and potentially leading to increased apoptosis of tumor cells with activated canonical Wnt signaling (PMID: 28500235, PMID: 30793158).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
CTNNB1 act mut hepatocellular carcinoma predicted - sensitive Tegavivint Phase Ib/II Actionable In a Phase I/II trial, Tegavivint (BC2059) treatment was tolerated and demonstrated preliminary efficacy with 1 partial response (PR) and stable disease (SD) in 8 of 15 evaluable patients with advanced hepatocellular carcinoma, 6 of the 7 patients harboring CTNNB1 activation mutations achieved a best response of PR or SD, comparing to 3 in 8 of the CTNNB1 wild-type patients (Cancer Res (2025) 85 (8_Supplement_2): CT032; NCT05797805). detail...

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04851119 Phase Ib/II Tegavivint Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors Recruiting USA 0
NCT05755087 Phase I Tegavivint Tegavivint for Treating Patients With Relapsed or Refractory Large B-Cell Lymphoma Recruiting USA 0
NCT03459469 Phase I Tegavivint Phase I, Open-label, Non-randomized Study to Evaluate Safety of BC2059 Completed USA | CAN 0
NCT05797805 Phase Ib/II Tegavivint Lenvatinib + Tegavivint Cabozantinib + Tegavivint A Study of Tegavivint (BC2059) in Patients With Advanced Hepatocellular Carcinoma Recruiting USA | CAN 0


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