BRAF N486_L495del
Gene Variant Detail

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Gene BRAF
Variant N486_L495del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions BRAF N486_L495del results in the deletion of ten amino acids within the protein kinase domain of the Braf protein (UniProt.org). N486_L495del has not been characterized in the scientific literature and therefore, its effect on Braf protein function is unknown (PubMed, Mar 2026).
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF N486_L495del

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Transcript NM_004333.6
gDNA chr7:g.140778023_140778052del30
cDNA c.1456_1485del30
Protein p.N486_L495delNVTAPTPQQL
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001378475.1 chr7:g.140753386_140754208del823 c.1457_1486del823 p.H486_F495delHRDLKSNNIF RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140778023_140778052del30 c.1456_1485del30 p.N486_L495delNVTAPTPQQL RefSeq GRCh38/hg38
NM_001378469.1 chr7:g.140777055_140777084del30 c.1456_1485del30 p.T486_M495delTRHVNILLFM RefSeq GRCh38/hg38
XM_047420766.1 chr7:g.140777085_140778016del932 c.1456_1485del932 p.F486_K495delFKNEVGVLRK RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140778023_140778052del30 c.1456_1485del30 p.N486_L495delNVTAPTPQQL RefSeq GRCh38/hg38
NM_001374244.1 chr7:g.140781643_140781672del30 c.1456_1485del30 p.S486_G495delSSDDWEIPDG RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140778023_140778052del30 c.1456_1485del30 p.N486_L495del RefSeq GRCh38/hg38
NM_001378470.1 chr7:g.140777019_140777048del30 c.1456_1485del30 p.S486_T495delSTKPQLAIVT RefSeq GRCh38/hg38
NM_001378471.1 chr7:g.140777010_140777039del30 c.1456_1485del30 p.P486_C495delPQLAIVTQWC RefSeq GRCh38/hg38
XM_017012559.2 chr7:g.140781643_140781672del30 c.1456_1485del30 p.S486_G495delSSDDWEIPDG RefSeq GRCh38/hg38
NM_001378467.1 chr7:g.140778032_140778061del30 c.1456_1485del30 p.K486_P495delKMLNVTAPTP RefSeq GRCh38/hg38
NM_001374258.1 chr7:g.140781643_140781672del30 c.1456_1485del30 p.S486_G495delSSDDWEIPDG RefSeq GRCh38/hg38
XM_047420767.1 chr7:g.140781643_140781672del30 c.1456_1485del30 p.S486_G495delSSDDWEIPDG RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140778023_140778052del30 c.1456_1485del30 p.N486_L495delNVTAPTPQQL RefSeq GRCh38/hg38
XM_047420770.1 chr7:g.140734699_140734728del30 c.1457_1486del30 p.I486_L495delIHRSASEPSL RefSeq GRCh38/hg38
NM_001378472.1 chr7:g.140776965_140776994del30 c.1457_1486del30 p.Y486_K495delYHHLHIIETK RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140778023_140778052del30 c.1456_1485del30 p.N486_L495delNVTAPTPQQL RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.140778023_140778052del30 c.1456_1485del30 p.N486_L495delNVTAPTPQQL RefSeq GRCh38/hg38
NM_001378473.1 chr7:g.140776965_140776994del30 c.1457_1486del30 p.Y486_K495delYHHLHIIETK RefSeq GRCh38/hg38
XM_047420768.1 chr7:g.140781643_140781672del30 c.1456_1485del30 p.S486_G495delSSDDWEIPDG RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140778023_140778052del30 c.1456_1485del30 p.N486_L495del RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References