BRAF N486_L495del
Gene Variant Detail

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Gene BRAF
Variant N486_L495del
Impact List deletion
Protein Effect gain of function - predicted
Gene Variant Descriptions BRAF N486_L495del results in the deletion of ten amino acids within the alphaC-helix region in the protein kinase domain of the Braf protein (PMID: 26732095). N486_L495del has not been characterized, however, is predicted to lead to a gain of protein function due to other characterized BRAF deletions in the same region (PMID: 26732095).
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF act mut BRAF N486_L495del

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Transcript NM_004333.6
gDNA chr7:g.140778023_140778052del30
cDNA c.1456_1485del30
Protein p.N486_L495delNVTAPTPQQL
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017012559.2 chr7:g.140781643_140781672del30 c.1456_1485del30 p.S486_G495delSSDDWEIPDG RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140778023_140778052del30 c.1456_1485del30 p.N486_L495del RefSeq GRCh38/hg38
NM_001374258.1 chr7:g.140781643_140781672del30 c.1456_1485del30 p.S486_G495delSSDDWEIPDG RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140778023_140778052del30 c.1456_1485del30 p.N486_L495delNVTAPTPQQL RefSeq GRCh38/hg38
XM_047420770.1 chr7:g.140734699_140734728del30 c.1457_1486del30 p.I486_L495delIHRSASEPSL RefSeq GRCh38/hg38
NM_001378469.1 chr7:g.140777055_140777084del30 c.1456_1485del30 p.T486_M495delTRHVNILLFM RefSeq GRCh38/hg38
NM_001378470.1 chr7:g.140777019_140777048del30 c.1456_1485del30 p.S486_T495delSTKPQLAIVT RefSeq GRCh38/hg38
NM_001374244.1 chr7:g.140781643_140781672del30 c.1456_1485del30 p.S486_G495delSSDDWEIPDG RefSeq GRCh38/hg38
NM_001378472.1 chr7:g.140776965_140776994del30 c.1457_1486del30 p.Y486_K495delYHHLHIIETK RefSeq GRCh38/hg38
NM_001378473.1 chr7:g.140776965_140776994del30 c.1457_1486del30 p.Y486_K495delYHHLHIIETK RefSeq GRCh38/hg38
NM_001378475.1 chr7:g.140753386_140754208del823 c.1457_1486del823 p.H486_F495delHRDLKSNNIF RefSeq GRCh38/hg38
NM_001378467.1 chr7:g.140778032_140778061del30 c.1456_1485del30 p.K486_P495delKMLNVTAPTP RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.140778023_140778052del30 c.1456_1485del30 p.N486_L495delNVTAPTPQQL RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140778023_140778052del30 c.1456_1485del30 p.N486_L495delNVTAPTPQQL RefSeq GRCh38/hg38
NM_001378471.1 chr7:g.140777010_140777039del30 c.1456_1485del30 p.P486_C495delPQLAIVTQWC RefSeq GRCh38/hg38
XM_047420766.1 chr7:g.140777085_140778016del932 c.1456_1485del932 p.F486_K495delFKNEVGVLRK RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140778023_140778052del30 c.1456_1485del30 p.N486_L495del RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140778023_140778052del30 c.1456_1485del30 p.N486_L495delNVTAPTPQQL RefSeq GRCh38/hg38
XM_047420767.1 chr7:g.140781643_140781672del30 c.1456_1485del30 p.S486_G495delSSDDWEIPDG RefSeq GRCh38/hg38
XM_047420768.1 chr7:g.140781643_140781672del30 c.1456_1485del30 p.S486_G495delSSDDWEIPDG RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140778023_140778052del30 c.1456_1485del30 p.N486_L495delNVTAPTPQQL RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References