Gene Variant Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene BRAF
Variant N486_L495del
Impact List deletion
Protein Effect gain of function - predicted
Gene Variant Descriptions BRAF N486_L495del results in the deletion of ten amino acids within the alphaC-helix region in the protein kinase domain of the Braf protein (PMID: 26732095). N486_L495del has not been characterized, however, is predicted to lead to a gain of protein function due to other characterized BRAF deletions in the same region (PMID: 26732095).
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF act mut BRAF N486_L495del

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_004333.6
gDNA chr7:g.140778023_140778052del30
cDNA c.1456_1485del30
Protein p.N486_L495delNVTAPTPQQL
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001374258.1 chr7:g.140781643_140781672del30 c.1456_1485del30 p.S486_G495delSSDDWEIPDG RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.140778023_140778052del30 c.1456_1485del30 p.N486_L495delNVTAPTPQQL RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140778023_140778052del30 c.1456_1485del30 p.N486_L495del RefSeq GRCh38/hg38
NM_001378471.1 chr7:g.140777010_140777039del30 c.1456_1485del30 p.P486_C495delPQLAIVTQWC RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140778023_140778052del30 c.1456_1485del30 p.N486_L495delNVTAPTPQQL RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140778023_140778052del30 c.1456_1485del30 p.N486_L495delNVTAPTPQQL RefSeq GRCh38/hg38
NM_001378470.1 chr7:g.140777019_140777048del30 c.1456_1485del30 p.S486_T495delSTKPQLAIVT RefSeq GRCh38/hg38
NM_001378472.1 chr7:g.140776965_140776994del30 c.1457_1486del30 p.Y486_K495delYHHLHIIETK RefSeq GRCh38/hg38
XM_047420766.1 chr7:g.140777085_140778016del932 c.1456_1485del932 p.F486_K495delFKNEVGVLRK RefSeq GRCh38/hg38
NM_001378469.1 chr7:g.140777055_140777084del30 c.1456_1485del30 p.T486_M495delTRHVNILLFM RefSeq GRCh38/hg38
XM_047420768.1 chr7:g.140781643_140781672del30 c.1456_1485del30 p.S486_G495delSSDDWEIPDG RefSeq GRCh38/hg38
XM_047420770.1 chr7:g.140734699_140734728del30 c.1457_1486del30 p.I486_L495delIHRSASEPSL RefSeq GRCh38/hg38
XM_047420767.1 chr7:g.140781643_140781672del30 c.1456_1485del30 p.S486_G495delSSDDWEIPDG RefSeq GRCh38/hg38
NM_001378475.1 chr7:g.140753386_140754208del823 c.1457_1486del823 p.H486_F495delHRDLKSNNIF RefSeq GRCh38/hg38
NM_001378467.1 chr7:g.140778032_140778061del30 c.1456_1485del30 p.K486_P495delKMLNVTAPTP RefSeq GRCh38/hg38
NM_001378473.1 chr7:g.140776965_140776994del30 c.1457_1486del30 p.Y486_K495delYHHLHIIETK RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140778023_140778052del30 c.1456_1485del30 p.N486_L495delNVTAPTPQQL RefSeq GRCh38/hg38
NM_001374244.1 chr7:g.140781643_140781672del30 c.1456_1485del30 p.S486_G495delSSDDWEIPDG RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140778023_140778052del30 c.1456_1485del30 p.N486_L495delNVTAPTPQQL RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140778023_140778052del30 c.1456_1485del30 p.N486_L495del RefSeq GRCh38/hg38
XM_017012559.2 chr7:g.140781643_140781672del30 c.1456_1485del30 p.S486_G495delSSDDWEIPDG RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References